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Mitoxantrone Loaded Superparamagnetic Nanoparticles for Drug Targeting : A Versatile and Sensitive Method for Quantification of Drug Enrichment in Rabbit Tissues Using HPLC-UV
Joint Authors
Lyer, Stefan
Tietze, Rainer
Schreiber, Eveline
Alexiou, Christoph
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In medicine, superparamagnetic nanoparticles bound to chemotherapeutics are currently investigated for their feasibility in local tumor therapy.
After intraarterial application, these particles can be accumulated in the targeted area by an external magnetic field to increase the drug concentration in the region of interest (Magnetic-Drug-Targeting).
We here present an analytical method (HPLC-UV), to detect pure or ferrofluid-bound mitoxantrone in a complex matrix even in trace amounts in order to perform biodistribution studies.
Mitoxantrone could be extracted in high yields from different tissues.
Recovery of mitoxantrone in liver tissue (5000 ng/g) was 76±2%.
The limit of quantification of mitoxantrone standard was 10 ng/mL ±12%.
Validation criteria such as linearity, precision, and stability were evaluated in ranges achieving the FDA requirements.
As shown for pilot samples, biodistribution studies can easily be performed after application of pure or ferrofluid-bound mitoxantrone.
American Psychological Association (APA)
Tietze, Rainer& Schreiber, Eveline& Lyer, Stefan& Alexiou, Christoph. 2010. Mitoxantrone Loaded Superparamagnetic Nanoparticles for Drug Targeting : A Versatile and Sensitive Method for Quantification of Drug Enrichment in Rabbit Tissues Using HPLC-UV. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-483885
Modern Language Association (MLA)
Tietze, Rainer…[et al.]. Mitoxantrone Loaded Superparamagnetic Nanoparticles for Drug Targeting : A Versatile and Sensitive Method for Quantification of Drug Enrichment in Rabbit Tissues Using HPLC-UV. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-483885
American Medical Association (AMA)
Tietze, Rainer& Schreiber, Eveline& Lyer, Stefan& Alexiou, Christoph. Mitoxantrone Loaded Superparamagnetic Nanoparticles for Drug Targeting : A Versatile and Sensitive Method for Quantification of Drug Enrichment in Rabbit Tissues Using HPLC-UV. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-483885
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483885