Molecular Events in Primary and Metastatic Colorectal Carcinoma : A Review
Joint Authors
Senger, Jenna-Lynn
Kanthan, Rani
Kanthan, Selliah Chandra
Source
Pathology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-09
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Colorectal cancer (CRC) is a heterogeneous disease, developing through a multipathway sequence of events guided by clonal selections.
Pathways included in the development of CRC may be broadly categorized into (a) genomic instability, including chromosomal instability (CIN), microsatellite instability (MSI), and CpG island methylator phenotype (CIMP), (b) genomic mutations including suppression of tumour suppressor genes and activation of tumour oncogenes, (c) microRNA, and (d) epigenetic changes.
As cancer becomes more advanced, invasion and metastases are facilitated through the epithelial-mesenchymal transition (EMT), with additional genetic alterations.
Despite ongoing identification of genetic and epigenetic markers and the understanding of alternative pathways involved in the development and progression of this disease, CRC remains the second highest cause of malignancy-related mortality in Canada.
The molecular events that underlie the tumorigenesis of primary and metastatic colorectal carcinoma are detailed in this manuscript.
American Psychological Association (APA)
Kanthan, Rani& Senger, Jenna-Lynn& Kanthan, Selliah Chandra. 2012. Molecular Events in Primary and Metastatic Colorectal Carcinoma : A Review. Pathology Research International،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-483913
Modern Language Association (MLA)
Kanthan, Rani…[et al.]. Molecular Events in Primary and Metastatic Colorectal Carcinoma : A Review. Pathology Research International No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-483913
American Medical Association (AMA)
Kanthan, Rani& Senger, Jenna-Lynn& Kanthan, Selliah Chandra. Molecular Events in Primary and Metastatic Colorectal Carcinoma : A Review. Pathology Research International. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-483913
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483913