The Effect of Bradykinin B2 Receptor Polymorphisms on the Susceptibility and Severity of Osteoarthritis in a Chinese Cohort
Joint Authors
Fan, Qing-Yu
Shan, Le-Qun
Chen, Shuo
Zhou, Yong
Li, Jun
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
The B2-bradykinin receptor (BDKRB2) has been reported to associate with onset and development of Osteoarthritis (OA); however, the role of BDKRB2 genetic polymorphisms in OA remains unknown.
Method.
A total of 245 patients with primary knee OA and 264 healthy volunteer were recruited.
BDKRB2 gene polymorphisms, −58T/C and +9/−9 bp polymorphisms, were genotyped.
Results.
The genotype distributions and allele frequencies of +9/−9 bp polymorphisms significantly differed between OA and control subjects.
Logistic regression analysis showed carriers with −9/−9 genotype had a significantly increased risk for knee OA compared with the +9/+9 genotype (adjusted OR=2.356, P<0.001).
The OR for −9 allele carriage was significantly higher than +9 allele carriage (adjusted OR=1.52, P<0.001).
The +9/−9 bp polymorphisms also determined the OA radiographic severity.
The presence of −9 bp was associated with severer OA.
The −58T/C polymorphisms did not affect OA risk and severity.
Conclusion.
The +9/−9 bp polymorphisms of BDKRB2 gene may be used as a genetic marker for the susceptibility and severity of OA.
American Psychological Association (APA)
Chen, Shuo& Zhou, Yong& Li, Jun& Shan, Le-Qun& Fan, Qing-Yu. 2012. The Effect of Bradykinin B2 Receptor Polymorphisms on the Susceptibility and Severity of Osteoarthritis in a Chinese Cohort. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-483927
Modern Language Association (MLA)
Chen, Shuo…[et al.]. The Effect of Bradykinin B2 Receptor Polymorphisms on the Susceptibility and Severity of Osteoarthritis in a Chinese Cohort. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-483927
American Medical Association (AMA)
Chen, Shuo& Zhou, Yong& Li, Jun& Shan, Le-Qun& Fan, Qing-Yu. The Effect of Bradykinin B2 Receptor Polymorphisms on the Susceptibility and Severity of Osteoarthritis in a Chinese Cohort. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-483927
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483927