Osteogenic Activity of Locally Applied Small Molecule Drugs in a Rat Femur Defect Model
Joint Authors
Wadsworth, Scott
Cottrell, Jessica A.
Schachter, Deborah
Kapadia, Rasesh
Gundlapalli, Rama
Vales, Francis M.
O'Connor, J. Patrick
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The long-term success of arthroplastic joints is dependent on the stabilization of the implant within the skeletal site.
Movement of the arthroplastic implant within the bone can stimulate osteolysis, and therefore methods which promote rigid fixation or bone growth are expected to enhance implant stability and the long-term success of joint arthroplasty.
In the present study, we used a simple bilateral bone defect model to analyze the osteogenic activity of three small-molecule drug implants via microcomputerized tomography (micro-CT) and histomorphometry.
In this study, we show that local delivery of alendronate, but not lovastatin or omeprazole, led to significant new bone formation at the defect site.
Since alendronate impedes osteoclast-development, it is theorized that alendronate treatment results in a net increase in bone formation by preventing osteoclast mediated remodeling of the newly formed bone and upregulating osteoblasts.
American Psychological Association (APA)
Cottrell, Jessica A.& Vales, Francis M.& Schachter, Deborah& Wadsworth, Scott& Gundlapalli, Rama& Kapadia, Rasesh…[et al.]. 2010. Osteogenic Activity of Locally Applied Small Molecule Drugs in a Rat Femur Defect Model. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-483928
Modern Language Association (MLA)
Cottrell, Jessica A.…[et al.]. Osteogenic Activity of Locally Applied Small Molecule Drugs in a Rat Femur Defect Model. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-483928
American Medical Association (AMA)
Cottrell, Jessica A.& Vales, Francis M.& Schachter, Deborah& Wadsworth, Scott& Gundlapalli, Rama& Kapadia, Rasesh…[et al.]. Osteogenic Activity of Locally Applied Small Molecule Drugs in a Rat Femur Defect Model. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-483928
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483928