Angiogenic Signalling Pathways Altered in Gliomas : Selection Mechanisms for More Aggressive Neoplastic Subpopulations with Invasive Phenotype
Joint Authors
Ortuzar, Naiara
Bengoetxea, Harkaitz
Bulnes, Susana
Argandoña, Enrike G.
Rico-Barrio, Irantzu
Lafuente, José V.
Garcia-Blanco, Álvaro
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The angiogenesis process is a key event for glioma survival, malignancy and growth.
The start of angiogenesis is mediated by a cascade of intratumoural events: alteration of the microvasculature network; a hypoxic microenvironment; adaptation of neoplastic cells and synthesis of pro-angiogenic factors.
Due to a chaotic blood flow, a consequence of an aberrant microvasculature, tissue hypoxia phenomena are induced.
Hypoxia inducible factor 1 is a major regulator in glioma invasiveness and angiogenesis.
Clones of neoplastic cells with stem cell characteristics are selected by HIF-1.
These cells, called “glioma stem cells” induce the synthesis of vascular endothelial growth factor.
This factor is a pivotal mediator of angiogenesis.
To elucidate the role of these angiogenic mediators during glioma growth, we have used a rat endogenous glioma model.
Gliomas induced by prenatal ENU administration allowed us to study angiogenic events from early to advanced tumour stages.
Events such as microvascular aberrations, hypoxia, GSC selection and VEGF synthesis may be studied in depth.
Our data showed that for the treatment of gliomas, developing anti-angiogenic therapies could be aimed at GSCs, HIF-1 or VEGF.
The ENU-glioma model can be considered to be a useful option to check novel designs of these treatment strategies.
American Psychological Association (APA)
Bulnes, Susana& Bengoetxea, Harkaitz& Ortuzar, Naiara& Argandoña, Enrike G.& Garcia-Blanco, Álvaro& Rico-Barrio, Irantzu…[et al.]. 2012. Angiogenic Signalling Pathways Altered in Gliomas : Selection Mechanisms for More Aggressive Neoplastic Subpopulations with Invasive Phenotype. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-483952
Modern Language Association (MLA)
Bulnes, Susana…[et al.]. Angiogenic Signalling Pathways Altered in Gliomas : Selection Mechanisms for More Aggressive Neoplastic Subpopulations with Invasive Phenotype. Journal of Signal Transduction No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-483952
American Medical Association (AMA)
Bulnes, Susana& Bengoetxea, Harkaitz& Ortuzar, Naiara& Argandoña, Enrike G.& Garcia-Blanco, Álvaro& Rico-Barrio, Irantzu…[et al.]. Angiogenic Signalling Pathways Altered in Gliomas : Selection Mechanisms for More Aggressive Neoplastic Subpopulations with Invasive Phenotype. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-483952
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483952