![](/images/graphics-bg.png)
Early Treatment Response Monitoring Using 2-Deoxy-2-[18F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts
Joint Authors
Lee, David Y.
Huang, Jiayi
Yan, Di
Wilson, George D.
Amin, Mitual
Chunta, John L.
Oliver Wong, Ching-Yee
Marples, Brian
Grills, Inga S.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
To determine the optimal timing and analytic method of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (PET) imaging during fractionated radiotherapy (RT) to predict tumor control.
Methods.
Ten head neck squamous cell carcinoma xenografts derived from the UT-14-SCC cell line were irradiated with 50 Gy at 2 Gy per day over 5 weeks.
Dynamic PET scans were acquired over 70 minutes at baseline (week 0) and weekly for seven weeks.
PET data were analyzed using standard uptake value (SUV), retention index (RI), sensitivity factor (SF), and kinetic index (Ki).
Results.
Four xenografts had local failure (LF) and 6 had local control.
Eighty scans from week 0 to week 7 were analyzed.
RI and SF after 10 Gy appeared to be the optimal predictors for LF.
In contrast, SUV and Ki during RT were not significant predictors for LF.
Conclusion.
RI and SF of PET obtained after the first week of fractionated RT were the optimal methods and timing to predict tumor control.
American Psychological Association (APA)
Huang, Jiayi& Chunta, John L.& Amin, Mitual& Lee, David Y.& Grills, Inga S.& Oliver Wong, Ching-Yee…[et al.]. 2014. Early Treatment Response Monitoring Using 2-Deoxy-2-[18F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-483965
Modern Language Association (MLA)
Huang, Jiayi…[et al.]. Early Treatment Response Monitoring Using 2-Deoxy-2-[18F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-483965
American Medical Association (AMA)
Huang, Jiayi& Chunta, John L.& Amin, Mitual& Lee, David Y.& Grills, Inga S.& Oliver Wong, Ching-Yee…[et al.]. Early Treatment Response Monitoring Using 2-Deoxy-2-[18F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-483965
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483965