TLRs, NF-κB, JNK, and Liver Regeneration
Joint Authors
Source
Gastroenterology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
While hepatocytes rarely undergo proliferation in normal livers, they quickly induce proliferation in response to loss of liver mass by toxin or inflammation-induced hepatocyte injury, trauma, or surgical resection, leading to a restoration of liver mass to its original size.
Recent studies suggest that Toll-like receptor (TLR) signaling participates in this regenerative response.
Myeloid differentiation factor (MyD88), a common adaptor molecule in the TLR, IL-1 and IL-18 receptor signaling, plays a key role, at least, in the early phase of liver regeneration.
Currently, definite ligands which bind to TLRs and initiate this process are still unclear.
TLRs stimulated by their corresponding ligands, as well as tumor necrosis factor (TNF) receptors (TNFRs), can activate downstream signal molecules, including transcription factor nuclear factor (NF)-κB and c-Jun N-terminal kinase (JNK).
Previous studies have revealed the important role of TNF receptor signaling, NF-κB, and JNK in liver regeneration by using hepatocyte-specific gene-modified animals.
This review will summarize the current knowledge of TLR signaling and their related molecules in liver regeneration.
We will also discuss whether modulating these factors may become new therapeutic strategies to promote liver regeneration in various clinical situations.
American Psychological Association (APA)
Iimuro, Yuji& Fujimoto, Jiro. 2010. TLRs, NF-κB, JNK, and Liver Regeneration. Gastroenterology Research and Practice،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-483971
Modern Language Association (MLA)
Iimuro, Yuji& Fujimoto, Jiro. TLRs, NF-κB, JNK, and Liver Regeneration. Gastroenterology Research and Practice No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-483971
American Medical Association (AMA)
Iimuro, Yuji& Fujimoto, Jiro. TLRs, NF-κB, JNK, and Liver Regeneration. Gastroenterology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-483971
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483971