Peripheral Pathways in the Food-Intake Control towards the Adipose-Intestinal Missing Link
Joint Authors
Flores-Merino, Miriam V.
Domínguez García, Ma. Victoria
Camarillo Romero, María del Socorro
Mendieta Zeron, Hugo
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In the physiological state a multitude of gut hormones are released into the circulation at the same time depending on the quality and quantity of the diet.
These hormones interact with receptors at various points in the “gut-brain axis” to affect short-term and intermediate-term feelings of hunger and satiety.
The combined effects of macronutrients on the predominant gut hormone secretion are still poorly understood.
Besides, adipokines form an important part of an “adipoinsular axis” dysregulation which may contribute to β-cell failure and hence to type 2 diabetes mellitus (T2DM).
Even more, gestational diabetes mellitus (GDM) and T2DM seem to share a genetic basis.
In susceptible individuals, chronic exaggerated stimulation of the proximal gut with fat and carbohydrates may induce overproduction of an unknown factor that causes impairment of incretin production and/or action, leading to insufficient or untimely production of insulin, so that glucose intolerance develops.
The bypass of the duodenum and jejunum might avoid a putative hormone overproduction in the proximal foregut in diabetic patients that might counteract the action of insulin, while the early presentation of undigested or incompletely digested food to the ileum may anticipate the production of hormones such as GLP1, further improving insulin action.
American Psychological Association (APA)
Mendieta Zeron, Hugo& Domínguez García, Ma. Victoria& Camarillo Romero, María del Socorro& Flores-Merino, Miriam V.. 2013. Peripheral Pathways in the Food-Intake Control towards the Adipose-Intestinal Missing Link. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-483984
Modern Language Association (MLA)
Mendieta Zeron, Hugo…[et al.]. Peripheral Pathways in the Food-Intake Control towards the Adipose-Intestinal Missing Link. International Journal of Endocrinology No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-483984
American Medical Association (AMA)
Mendieta Zeron, Hugo& Domínguez García, Ma. Victoria& Camarillo Romero, María del Socorro& Flores-Merino, Miriam V.. Peripheral Pathways in the Food-Intake Control towards the Adipose-Intestinal Missing Link. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-483984
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483984