Endothelial Dysfunction in Experimental Models of Arterial Hypertension : Cause or Consequence?
Author
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-13
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Hypertension is a risk factor for other cardiovascular diseases and endothelial dysfunction was found in humans as well as in various commonly employed animal experimental models of arterial hypertension.
Data from the literature indicate that, in general, endothelial dysfunction would not be the cause of experimental hypertension and may rather be secondary, that is, resulting from high blood pressure (BP).
The initial mechanism of endothelial dysfunction itself may be associated with a lack of endothelium-derived relaxing factors (mainly nitric oxide) and/or accentuation of various endothelium-derived constricting factors.
The involvement and role of endothelium-derived factors in the development of endothelial dysfunction in individual experimental models of hypertension may vary, depending on the triggering stimulus, strain, age, and vascular bed investigated.
This brief review was focused on the participation of endothelial dysfunction, individual endothelium-derived factors, and their mechanisms of action in the development of high BP in the most frequently used rodent experimental models of arterial hypertension, including nitric oxide deficient models, spontaneous (pre)hypertension, stress-induced hypertension, and selected pharmacological and diet-induced models.
American Psychological Association (APA)
Bernatova, Iveta. 2014. Endothelial Dysfunction in Experimental Models of Arterial Hypertension : Cause or Consequence?. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-483992
Modern Language Association (MLA)
Bernatova, Iveta. Endothelial Dysfunction in Experimental Models of Arterial Hypertension : Cause or Consequence?. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-483992
American Medical Association (AMA)
Bernatova, Iveta. Endothelial Dysfunction in Experimental Models of Arterial Hypertension : Cause or Consequence?. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-483992
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483992