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Modulation of Antioxidant Enzymatic Activities by Certain Antiepileptic Drugs (Valproic Acid, Oxcarbazepine, and Topiramate) : Evidence in Humans and Experimental Models
Joint Authors
Floriano-Sánchez, Esaú
Ortega-Cuellar, Daniel
Cárdenas-Rodríguez, Noemí
Montesinos-Correa, Hortencia
Rivera-Espinosa, Liliana
Coballase-Urrutia, Elvia
Romero-Toledo, Arantxa
Sampieri, Aristides III
Carmona-Aparicio, Liliana
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
It is estimated that at least 100 million people worldwide will suffer from epilepsy at some point in their lives.
This neurological disorder induces brain death due to the excessive liberation of glutamate, which activates the postsynaptic N-methyl-D-aspartic acid (NMDA) receptors, which in turn cause the reuptake of intracellular calcium (excitotoxicity).
This excitotoxicity elicits a series of events leading to nitric oxide synthase (NOS) activation and the generation of reactive oxygen species (ROS).
Several studies in experimental models and in humans have demonstrated that certain antiepileptic drugs (AEDs) exhibit antioxidant effects by modulating the activity of various enzymes associated with this type of stress.
Considering the above-mentioned data, we aimed to compile evidence elucidating how AEDs such as valproic acid (VPA), oxcarbazepine (OXC), and topiramate (TPM) modulate oxidative stress.
American Psychological Association (APA)
Cárdenas-Rodríguez, Noemí& Coballase-Urrutia, Elvia& Rivera-Espinosa, Liliana& Romero-Toledo, Arantxa& Sampieri, Aristides III& Ortega-Cuellar, Daniel…[et al.]. 2013. Modulation of Antioxidant Enzymatic Activities by Certain Antiepileptic Drugs (Valproic Acid, Oxcarbazepine, and Topiramate) : Evidence in Humans and Experimental Models. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-484007
Modern Language Association (MLA)
Cárdenas-Rodríguez, Noemí…[et al.]. Modulation of Antioxidant Enzymatic Activities by Certain Antiepileptic Drugs (Valproic Acid, Oxcarbazepine, and Topiramate) : Evidence in Humans and Experimental Models. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-484007
American Medical Association (AMA)
Cárdenas-Rodríguez, Noemí& Coballase-Urrutia, Elvia& Rivera-Espinosa, Liliana& Romero-Toledo, Arantxa& Sampieri, Aristides III& Ortega-Cuellar, Daniel…[et al.]. Modulation of Antioxidant Enzymatic Activities by Certain Antiepileptic Drugs (Valproic Acid, Oxcarbazepine, and Topiramate) : Evidence in Humans and Experimental Models. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-484007
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484007