Myeloid-Derived Suppressor Cells in Sepsis
Joint Authors
Shu, Qiang
Lai, Dengming
Qin, Chao-Jin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Sepsis is a systemic, deleterious host response to widespread infection.
Patients with sepsis will have documented or suspected infection which can progress to a state of septic shock or acute organ dysfunction.
Since sepsis is responsible for nearly 3 million cases per year in China and severe sepsis is a common, expensive fatal condition in America, developing new therapies becomes a significant and worthwhile challenge.
Clinical research has shown that sepsis-associated immunosuppression plays a central role in patient mortality, and targeted immune-enhancing therapy may be an effective treatment approach in these patients.
As part of the inflammatory response during sepsis, there are elevations in the number of myeloid-derived suppressor cells (MDSCs).
MDSCs are a heterogeneous population of immature myeloid cells that possess immunosuppressive activities via suppressing T-cell proliferation and activation.
The role of MDSCs in sepsis remains uncertain.
Some believe activated MDSCs are beneficial to the sepsis host by increasing innate immune responses and antimicrobial activities, while others think expansion of MDSCs leads to adaptive immune suppression and secondary infection.
Herein, we discuss the complex role of MDSCs in immune regulation during sepsis, as well as the potential to target these cells for therapeutic benefit.
American Psychological Association (APA)
Lai, Dengming& Qin, Chao-Jin& Shu, Qiang. 2014. Myeloid-Derived Suppressor Cells in Sepsis. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-484026
Modern Language Association (MLA)
Lai, Dengming…[et al.]. Myeloid-Derived Suppressor Cells in Sepsis. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-484026
American Medical Association (AMA)
Lai, Dengming& Qin, Chao-Jin& Shu, Qiang. Myeloid-Derived Suppressor Cells in Sepsis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-484026
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484026