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Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis
Joint Authors
Randall, R. Lor
Lessnick, Stephen L.
Kowalewski, Ashley A.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Ewing's sarcoma is a highly aggressive pediatric tumor of bone that usually contains the characteristic chromosomal translocation t(11;22)(q24;q12).
This translocation encodes the oncogenic fusion protein EWS/FLI, which acts as an aberrant transcription factor to deregulate target genes necessary for oncogenesis.
One key feature of oncogenic transformation is dysregulation of cell cycle control.
It is therefore likely that EWS/FLI and other cooperating mutations in Ewing's sarcoma modulate the cell cycle to facilitate tumorigenesis.
This paper will summarize current published data associated with deregulation of the cell cycle in Ewing's sarcoma and highlight important questions that remain to be answered.
American Psychological Association (APA)
Kowalewski, Ashley A.& Randall, R. Lor& Lessnick, Stephen L.. 2010. Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis. Sarcoma،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-484032
Modern Language Association (MLA)
Kowalewski, Ashley A.…[et al.]. Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis. Sarcoma No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-484032
American Medical Association (AMA)
Kowalewski, Ashley A.& Randall, R. Lor& Lessnick, Stephen L.. Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis. Sarcoma. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-484032
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484032