Glucagon-Like Peptide-1 Gene Therapy
Joint Authors
Di Pasquale, Giovanni
Rowzee, Anne M.
Chiorini, John A.
Cawley, Niamh X.
Source
Experimental Diabetes Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Glucagon-like peptide 1 (GLP-1) is a small peptide component of the prohormone, proglucagon, that is produced in the gut.
Exendin-4, a GLP-1 receptor agonist originally isolated from the saliva of H.
suspectum or Gila monster, is a peptide that shares sequence and functional homology with GLP-1.
Both peptides have been demonstrated to stimulate insulin secretion, inhibit glucagon secretion, promote satiety and slow gastric emptying.
As such, GLP-1 and Exendin-4 have become attractive pharmaceutical targets as an adjunctive therapy for individuals with type II diabetes mellitus, with several products currently available clinically.
Herein we summarize the cell biology leading to GLP-1 production and secretion from intestinal L-cells and the endocrine functions of this peptide and Exendin-4 in humans.
Additionally, gene therapeutic applications of GLP-1 and Exendin-4 are discussed with a focus on recent work using the salivary gland as a gene therapy target organ for the treatment of diabetes mellitus.
American Psychological Association (APA)
Rowzee, Anne M.& Cawley, Niamh X.& Chiorini, John A.& Di Pasquale, Giovanni. 2011. Glucagon-Like Peptide-1 Gene Therapy. Experimental Diabetes Research،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-484062
Modern Language Association (MLA)
Rowzee, Anne M.…[et al.]. Glucagon-Like Peptide-1 Gene Therapy. Experimental Diabetes Research No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-484062
American Medical Association (AMA)
Rowzee, Anne M.& Cawley, Niamh X.& Chiorini, John A.& Di Pasquale, Giovanni. Glucagon-Like Peptide-1 Gene Therapy. Experimental Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-484062
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484062