Neurokinin-1 Receptor Antagonist Treatment in Polymicrobial Sepsis : Molecular Insights
Joint Authors
Koh, Yung-Hua
Hegde, Akhil
Bhatia, Madhav
Moochhala, Shabbir M.
Source
International Journal of Inflammation
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Neurokinin-1 receptor blocking has been shown to be beneficial against lung injury in polymicrobial sepsis.
In this paper, we evaluated the possible mediators and the mechanism involved.
Mice were subjected to cecal ligation and puncture (CLP-) induced sepsis or sham surgery.
Vehicle or SR140333 [1 mg/kg; subcutaneous (s.c.)] was administered to septic mice either 30 min before or 1 h after the surgery.
Lung tissue was collected 8 h after surgery and further analyzed.
CLP alone caused a significant increase in the activation of the transcription factors, protein kinase C-α, extracellular signal regulated kinases, neurokinin receptors, and substance P levels in lung when compared to sham-operated mice.
SR140333 injected pre- and post surgery significantly attenuated the activation of transcription factors and protein kinase C-α and the plasma levels of substance P compared to CLP-operated mice injected with the vehicle.
In addition, GR159897 (0.12 mg/kg; s.c.), a neurokinin-2 receptor antagonist, failed to show beneficial effects.
We conclude that substance P acting via neurokinin-1 receptor in sepsis initiated signaling cascade mediated mainly by protein kinase C-α, led to NF-κB and activator protein-1 activation, and further modulated proinflammatory mediators.
American Psychological Association (APA)
Hegde, Akhil& Koh, Yung-Hua& Moochhala, Shabbir M.& Bhatia, Madhav. 2010. Neurokinin-1 Receptor Antagonist Treatment in Polymicrobial Sepsis : Molecular Insights. International Journal of Inflammation،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-484068
Modern Language Association (MLA)
Hegde, Akhil…[et al.]. Neurokinin-1 Receptor Antagonist Treatment in Polymicrobial Sepsis : Molecular Insights. International Journal of Inflammation No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-484068
American Medical Association (AMA)
Hegde, Akhil& Koh, Yung-Hua& Moochhala, Shabbir M.& Bhatia, Madhav. Neurokinin-1 Receptor Antagonist Treatment in Polymicrobial Sepsis : Molecular Insights. International Journal of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-484068
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484068