Docking Studies of Binding of Ethambutol to the C-Terminal Domain of the Arabinosyltransferase from Mycobacterium tuberculosis
Joint Authors
Bunster, Marta
Ramirez-Tagle, Rodrigo
Kishore-Deb, Pran
Lobos-Gonzalez, Francisco
Glossman-Mitnik, Daniel
Ruiz-Nieto, Samuel
Salgado-Morán, Guillermo
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The binding of ethambutol to the C-terminal domain of the arabinosyltransferase from Mycobacterium tuberculosis was studied.
The analysis was performed using an in silico approach in order to find out, by docking calculations and energy descriptors, the conformer of Ethambutol that forms the most stable complex with the C-terminal domain of arabinosyltransferase.
The complex shows that location of the Ethambutol coincides with the cocrystallization ligand position and that amino acid residues ASH1051, ASN740, ASP1052, and ARG1055 should be critical in the binding of Ethambutol to C-terminal domain EmbC.
American Psychological Association (APA)
Salgado-Morán, Guillermo& Ramirez-Tagle, Rodrigo& Glossman-Mitnik, Daniel& Ruiz-Nieto, Samuel& Kishore-Deb, Pran& Bunster, Marta…[et al.]. 2013. Docking Studies of Binding of Ethambutol to the C-Terminal Domain of the Arabinosyltransferase from Mycobacterium tuberculosis. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-484076
Modern Language Association (MLA)
Salgado-Morán, Guillermo…[et al.]. Docking Studies of Binding of Ethambutol to the C-Terminal Domain of the Arabinosyltransferase from Mycobacterium tuberculosis. Journal of Chemistry No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-484076
American Medical Association (AMA)
Salgado-Morán, Guillermo& Ramirez-Tagle, Rodrigo& Glossman-Mitnik, Daniel& Ruiz-Nieto, Samuel& Kishore-Deb, Pran& Bunster, Marta…[et al.]. Docking Studies of Binding of Ethambutol to the C-Terminal Domain of the Arabinosyltransferase from Mycobacterium tuberculosis. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-484076
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484076