Relation of Serum Leptin and Adiponectin Level to Serum C-Reactive Protein : The INTERLIPID Study
Joint Authors
Nakamura, Yasuyuki
Kita, Yoshikuni
Masaki, Kamal H.
Rodriguez, Beatriz
Okayama, Akira
Miura, Katsuyuki
Ueshima, Hirotsugu
Okuda, Nagako
Stamler, Jeremiah
Choudhury, Sohel R.
Okamura, Tomonori
Source
International Journal of Vascular Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Despite considerable study, the relevance of leptin and adiponectin for atherosclerosis development is still unsettled.
We investigated relations of serum leptin and adiponectin to serum C-reactive protein (CRP), using the INTERLIPID dataset on Japanese emigrants living in Hawaii and Japanese in Japan.
Design and Methods.
Serum leptin, adiponectin, and CRP were measured by standardized methods in men and women of ages 40 to 59 years from two population samples, one Japanese-American in Hawaii (83 men, 89 women) and the other Japanese in central Japan (111 men, 104 women).
Participants with CRP >10 mg/L were excluded.
Results.
Sex-specific multiple linear regression analyses, with log-transformed leptin and adiponectin (log-leptin, log-adipo), site (Hawaii = 1, Japan = 0), SBP, HbA1c, smoking (cigarettes/day), and physical activity index score of the Framingham Offspring Study as covariates, showed that log-leptin directly related and log-adipo inversely related to log-CRP for both sexes (Ps < 0.05 to <0.01).
Addition to the model of BMI and interaction terms (BMI × log-leptin, BMI × log-adipo, SITE × log-leptin, SITE × log-adipo) resulted in disappearance of statistical significance except for direct relation of log-leptin to log-CRP in men (P=0.006).
Conclusions.
Leptin directly related to CRP independent of BMI and other confounding factors in men but not in women.
American Psychological Association (APA)
Nakamura, Yasuyuki& Ueshima, Hirotsugu& Okuda, Nagako& Miura, Katsuyuki& Kita, Yoshikuni& Okamura, Tomonori…[et al.]. 2013. Relation of Serum Leptin and Adiponectin Level to Serum C-Reactive Protein : The INTERLIPID Study. International Journal of Vascular Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-484086
Modern Language Association (MLA)
Nakamura, Yasuyuki…[et al.]. Relation of Serum Leptin and Adiponectin Level to Serum C-Reactive Protein : The INTERLIPID Study. International Journal of Vascular Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-484086
American Medical Association (AMA)
Nakamura, Yasuyuki& Ueshima, Hirotsugu& Okuda, Nagako& Miura, Katsuyuki& Kita, Yoshikuni& Okamura, Tomonori…[et al.]. Relation of Serum Leptin and Adiponectin Level to Serum C-Reactive Protein : The INTERLIPID Study. International Journal of Vascular Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-484086
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484086