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Cancer Cachexia : Mechanisms and Clinical Implications
Joint Authors
Donohoe, Claire L.
Ryan, Aoife M.
Reynolds, John V.
Source
Gastroenterology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Cachexia is a multifactorial process of skeletal muscle and adipose tissue atrophy resulting in progressive weight loss.
It is associated with poor quality of life, poor physical function, and poor prognosis in cancer patients.
It involves multiple pathways: procachectic and proinflammatory signals from tumour cells, systemic inflammation in the host, and widespread metabolic changes (increased resting energy expenditure and alterations in metabolism of protein, fat, and carbohydrate).
Whether it is primarily driven by the tumour or as a result of the host response to the tumour has yet to be fully elucidated.
Cachexia is compounded by anorexia and the relationship between these two entities has not been clarified fully.
Inconsistencies in the definition of cachexia have limited the epidemiological characterisation of the condition and there has been slow progress in identifying therapeutic agents and trialling them in the clinical setting.
Understanding the complex interplay of tumour and host factors will uncover new therapeutic targets.
American Psychological Association (APA)
Donohoe, Claire L.& Ryan, Aoife M.& Reynolds, John V.. 2011. Cancer Cachexia : Mechanisms and Clinical Implications. Gastroenterology Research and Practice،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-484094
Modern Language Association (MLA)
Donohoe, Claire L.…[et al.]. Cancer Cachexia : Mechanisms and Clinical Implications. Gastroenterology Research and Practice No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-484094
American Medical Association (AMA)
Donohoe, Claire L.& Ryan, Aoife M.& Reynolds, John V.. Cancer Cachexia : Mechanisms and Clinical Implications. Gastroenterology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-484094
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484094