Targeting Angiogenesis in Childhood Sarcomas
Joint Authors
Houghton, Peter J.
Bid, Hemant K.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Angiogenesis and vasculogenesis constitute two processes in the formation of new blood vessels and are essential for progression of solid tumors.
Consequently, targeting angiogenesis, and to a lesser extent vasculogenesis, has become a major focus in cancer drug development.
Angiogenesis inhibitors are now being tested in pediatric populations whereas inhibitors of vasculogenesis are in an earlier stage of development.
Despite the initial enthusiasm for targeting angiogenesis for treatment of cancer, clinical trials have shown only incremental increases in survival, and agents have been largely cytostatic rather than inducing tumor regressions.
Consequently, the role of such therapeutic approaches in the context of curative intent for childhood sarcomas is less clear.
Here we review the literature on blood vessel formation in sarcomas with a focus on pediatric sarcomas and developments in targeting angiogenesis for treatment of these rare cancers.
American Psychological Association (APA)
Bid, Hemant K.& Houghton, Peter J.. 2010. Targeting Angiogenesis in Childhood Sarcomas. Sarcoma،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-484101
Modern Language Association (MLA)
Bid, Hemant K.& Houghton, Peter J.. Targeting Angiogenesis in Childhood Sarcomas. Sarcoma No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-484101
American Medical Association (AMA)
Bid, Hemant K.& Houghton, Peter J.. Targeting Angiogenesis in Childhood Sarcomas. Sarcoma. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-484101
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484101