Dynamic Assessment of Fibrinogen Adsorption and Secondary Structure Perturbation
Joint Authors
Wright, Rupert
Khot, Gaurang
Kuforiji, Folashade
Roach, Paul
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Fibrinogen is a protein being of prime importance for the initiation of clotting and thrombus formation, readily adsorbed onto surfaces presenting both hydrophilic and hydrophobic nature.
The mechanism of adsorption, and thus the final presentation of this protein are therefore important for subsequent involvement for, for example, platelet adhesion.
Biological activity can be controlled through careful consideration of material design; here we report kinetic assessment of fibrinogen adsorption onto plasma polymerised allylamine (hydrophilic) and hexane (hydrophobic) surfaces, using FTIR-ATR to inform on kinetics of adsorption, secondary structure evaluation, and orientational variation.
Fibrinogen was found to respond differently to these two surfaces, adsorbing more rapidly to hydrophilic surfaces and losing an ordered secondary structure over a much longer timescale compared to hydrophobic surfaces.
American Psychological Association (APA)
Khot, Gaurang& Kuforiji, Folashade& Wright, Rupert& Roach, Paul. 2014. Dynamic Assessment of Fibrinogen Adsorption and Secondary Structure Perturbation. Conference Papers in Science،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-484105
Modern Language Association (MLA)
Khot, Gaurang…[et al.]. Dynamic Assessment of Fibrinogen Adsorption and Secondary Structure Perturbation. Conference Papers in Science No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-484105
American Medical Association (AMA)
Khot, Gaurang& Kuforiji, Folashade& Wright, Rupert& Roach, Paul. Dynamic Assessment of Fibrinogen Adsorption and Secondary Structure Perturbation. Conference Papers in Science. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-484105
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484105