Life-Threatening Adenovirus Infections in the Setting of the Immunocompromised Allogeneic Stem Cell Transplant Patients
Joint Authors
Fowler, Cedar J.
Troyer, Darcy
Dunlap, Jennifer
Stenzel, Peter
Maziarz, Richard T.
Epner, Elliot
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A single institution case series of adenovirus infections after allogeneic hematopoietic stem cell transplantation is presented to highlight the consideration for adenovirus infections as an etiology in patients with rapid hepatic or other sudden organ deterioration in the setting of apparent GVHD stabilization.
The series also highlights that survival is limited with these infections often due in part to concomitant opportunistic infections.
In addition, the pathophysiological events, such as GVHD and hepatic dysfunction, may complicate the clinical picture and delay therapy of an opportunistic infection.
This is particularly true for adenoviral infections as they also have a distinct clinical picture in immunocompromised patients when compared to immune competent patients.
Adenovirus infections also have the additional challenge that its treatment, cidofovir, has associated toxicities that can delay its administration.
Recent developments has yielded an assay that can be used in the early detection and for serial determinations of adenovirus in patients with advanced GVHD, as well as a new therapeutic agent currently undergoing clinical trials.
American Psychological Association (APA)
Fowler, Cedar J.& Dunlap, Jennifer& Troyer, Darcy& Stenzel, Peter& Epner, Elliot& Maziarz, Richard T.. 2010. Life-Threatening Adenovirus Infections in the Setting of the Immunocompromised Allogeneic Stem Cell Transplant Patients. Advances in Hematology،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-484106
Modern Language Association (MLA)
Fowler, Cedar J.…[et al.]. Life-Threatening Adenovirus Infections in the Setting of the Immunocompromised Allogeneic Stem Cell Transplant Patients. Advances in Hematology No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-484106
American Medical Association (AMA)
Fowler, Cedar J.& Dunlap, Jennifer& Troyer, Darcy& Stenzel, Peter& Epner, Elliot& Maziarz, Richard T.. Life-Threatening Adenovirus Infections in the Setting of the Immunocompromised Allogeneic Stem Cell Transplant Patients. Advances in Hematology. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-484106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484106