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Function and Characteristics of PINK1 in Mitochondria
Joint Authors
Kobayashi, Mayumi
Matsuda, Satoru
Kitagishi, Yasuko
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Mutations in phosphatase and tensin homologue-induced kinase 1 (PINK1) cause recessively inherited Parkinson’s disease, a neurodegenerative disorder linked to mitochondrial dysfunction.
Studies support the notion of neuroprotective roles for the PINK1, as it protects cells from damage-mediated mitochondrial dysfunction, oxidative stress, and cell apoptosis.
PARL is a mitochondrial resident rhomboid serine protease, and it has been reported to mediate the cleavage of the PINK1.
Interestingly, impaired mitophagy, an important autophagic quality control mechanism that clears the cells of damaged mitochondria, may also be an underlying mechanism of disease pathogenesis in patients for Parkinson’s disease with the PARL mutations.
Functional studies have revealed that PINK1 recruits Parkin to mitochondria to initiate the mitophagy.
PINK1 is posttranslationally processed, whose level is definitely regulated in healthy steady state of mitochondria.
As a consequence, PINK1 plays a pivotal role in mitochondrial healthy homeostasis.
American Psychological Association (APA)
Matsuda, Satoru& Kitagishi, Yasuko& Kobayashi, Mayumi. 2013. Function and Characteristics of PINK1 in Mitochondria. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-484114
Modern Language Association (MLA)
Matsuda, Satoru…[et al.]. Function and Characteristics of PINK1 in Mitochondria. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-484114
American Medical Association (AMA)
Matsuda, Satoru& Kitagishi, Yasuko& Kobayashi, Mayumi. Function and Characteristics of PINK1 in Mitochondria. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-484114
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484114