The Pathogenesis of Nontraumatic Osteonecrosis
Joint Authors
Keller, Thomas
Cui, Quanjun
Seamon, Jesse
Saleh, Jamal
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Nontraumatic osteonecrosis continues to be a challenging problem causing debilitating major joint diseases.
The etiology is multifactorial, but steroid- and alcohol-induced osteonecrosis contribute to more than two thirds of all cases with genetic risk factors playing an important role in many other cases, especially when they contribute to hypercoagulable states.
While the exact mechanisms remain elusive, many new insights have emerged from research in the last decade that have given us a clearer picture of the pathogenesis of nontraumatic osteonecrosis of the femoral head.
Progression to end stage osteonecrosis of the femoral head appears to be related to four main factors: interactions involving the differentiation pathway of osteoprogenitor cells that promote adipogenesis, decreased angiogenesis, direct suppression of osteogenic gene expression and proliferation of bone marrow stem cells, and genetic anomalies or other diseases that promote hypercoagulable states.
American Psychological Association (APA)
Seamon, Jesse& Keller, Thomas& Saleh, Jamal& Cui, Quanjun. 2012. The Pathogenesis of Nontraumatic Osteonecrosis. Arthritis،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-484133
Modern Language Association (MLA)
Seamon, Jesse…[et al.]. The Pathogenesis of Nontraumatic Osteonecrosis. Arthritis No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-484133
American Medical Association (AMA)
Seamon, Jesse& Keller, Thomas& Saleh, Jamal& Cui, Quanjun. The Pathogenesis of Nontraumatic Osteonecrosis. Arthritis. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-484133
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484133