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Glycoproteomics-Based Identification of Cancer Biomarkers
Joint Authors
Source
International Journal of Proteomics
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Protein glycosylation is one of the most common posttranslational modifications in mammalian cells.
It is involved in many biological pathways and molecular functions and is well suited for proteomics-based disease investigations.
Aberrant protein glycosylation may be associated with disease processes.
Specific glycoforms of glycoproteins may serve as potential biomarkers for the early detection of disease or as biomarkers for the evaluation of therapeutic efficacy for treatment of cancer, diabetes, and other diseases.
Recent technological developments, including lectin affinity chromatography and mass spectrometry, have provided researchers the ability to obtain detailed information concerning protein glycosylation.
These in-depth investigations, including profiling and quantifying glycoprotein expression, as well as comprehensive glycan structural analyses may provide important information leading to the development of disease-related biomarkers.
This paper describes methodologies for the detection of cancer-related glycoprotein and glycan structural alterations and briefly summarizes several current cancer-related findings.
American Psychological Association (APA)
Kim, Evelyn H.& Misek, David E.. 2011. Glycoproteomics-Based Identification of Cancer Biomarkers. International Journal of Proteomics،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-484153
Modern Language Association (MLA)
Kim, Evelyn H.& Misek, David E.. Glycoproteomics-Based Identification of Cancer Biomarkers. International Journal of Proteomics No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-484153
American Medical Association (AMA)
Kim, Evelyn H.& Misek, David E.. Glycoproteomics-Based Identification of Cancer Biomarkers. International Journal of Proteomics. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-484153
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484153