Selection of Conserved Epitopes from Hepatitis C Virus for Pan-Populational Stimulation of T-Cell Responses
Joint Authors
Lafuente, Esther M.
Flower, Darren R.
Reche, Pedro A.
Molero-Abraham, Magdalena
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The hepatitis C virus (HCV) is able to persist as a chronic infection, which can lead to cirrhosis and liver cancer.
There is evidence that clearance of HCV is linked to strong responses by CD8 cytotoxic T lymphocytes (CTLs), suggesting that eliciting CTL responses against HCV through an epitope-based vaccine could prove an effective means of immunization.
However, HCV genomic plasticity as well as the polymorphisms of HLA I molecules restricting CD8 T-cell responses challenges the selection of epitopes for a widely protective vaccine.
Here, we devised an approach to overcome these limitations.
From available databases, we first collected a set of 245 HCV-specific CD8 T-cell epitopes, all known to be targeted in the course of a natural infection in humans.
After a sequence variability analysis, we next identified 17 highly invariant epitopes.
Subsequently, we predicted the epitope HLA I binding profiles that determine their potential presentation and recognition.
Finally, using the relevant HLA I-genetic frequencies, we identified various epitope subsets encompassing 6 conserved HCV-specific CTL epitopes each predicted to elicit an effective T-cell response in any individual regardless of their HLA I background.
We implemented this epitope selection approach for free public use at the EPISOPT web server.
American Psychological Association (APA)
Molero-Abraham, Magdalena& Lafuente, Esther M.& Flower, Darren R.& Reche, Pedro A.. 2013. Selection of Conserved Epitopes from Hepatitis C Virus for Pan-Populational Stimulation of T-Cell Responses. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-484154
Modern Language Association (MLA)
Molero-Abraham, Magdalena…[et al.]. Selection of Conserved Epitopes from Hepatitis C Virus for Pan-Populational Stimulation of T-Cell Responses. Clinical and Developmental Immunology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-484154
American Medical Association (AMA)
Molero-Abraham, Magdalena& Lafuente, Esther M.& Flower, Darren R.& Reche, Pedro A.. Selection of Conserved Epitopes from Hepatitis C Virus for Pan-Populational Stimulation of T-Cell Responses. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-484154
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484154