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Steroid-Refractory Acute GVHD : Predictors and Outcomes
Joint Authors
Champlin, Richard
Hosing, Chitra
Shpall, Elizabeth J.
Couriel, Daniel R.
Anderlini, Paolo
Rondon, Gabriela
Khouri, Issa F.
Saliba, Rima M.
Andersson, Borje S.
Westin, Jason R.
De Lima, Marcos
Alousi, Amin
Qazilbash, Muzaffar H.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Patients with steroid-resistant acute graft versus host disease (aGVHD) have a dismal prognosis, with mortality rates in excess of 90%.
We sought to identify a subgroup of patients less likely to benefit from initial therapy with corticosteroids as well as the impact of response on day 14 on outcome.
Retrospective evaluation was performed of patients with biopsy-proven aGVHD treated with corticosteroids after allogeneic HSCT at M.D.
Anderson Cancer Center from 1998 through 2002 (N=287).
Overall response to first-line therapy on day 14 was 56%.
Grade III-IV aGVHD and hyperacute GVHD were the most significant factors predicting failure.
Patients who fail to respond to steroids by day 14 should be considered for clinical trials.
Severity of aGVHD, hyperacute GVHD, and sex mismatch could be integrated into prognostic scoring systems which may allow for pretreatment identification of patients unlikely to benefit from standard therapy with corticosteroids.
American Psychological Association (APA)
Westin, Jason R.& Saliba, Rima M.& De Lima, Marcos& Alousi, Amin& Hosing, Chitra& Qazilbash, Muzaffar H.…[et al.]. 2011. Steroid-Refractory Acute GVHD : Predictors and Outcomes. Advances in Hematology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-484155
Modern Language Association (MLA)
Westin, Jason R.…[et al.]. Steroid-Refractory Acute GVHD : Predictors and Outcomes. Advances in Hematology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-484155
American Medical Association (AMA)
Westin, Jason R.& Saliba, Rima M.& De Lima, Marcos& Alousi, Amin& Hosing, Chitra& Qazilbash, Muzaffar H.…[et al.]. Steroid-Refractory Acute GVHD : Predictors and Outcomes. Advances in Hematology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-484155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484155