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4-Hydroxyhexenal- and 4-Hydroxynonenal-Modified Proteins in Pterygia
Joint Authors
Tanito, Masaki
Kaidzu, Sachiko
Ohira, Akihiro
Okuno, Tsutomu
Sano, Ichiya
Hara, Katsunori
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Oxidative stress has been suspected of contributing to the pathogenesis of pterygia.
We evaluated the immunohistochemical localization of the markers of oxidative stress, that is, the proteins modified by 4-hydroxyhexenal (4-HHE) and 4-hydroxynonenal (4-HNE), which are reactive aldehydes derived from nonenzymatic oxidation of n-3 and n-6 polyunsaturated fatty acids, respectively.
In the pterygial head, labeling of 4-HHE- and 4-HNE-modified proteins was prominent in the nuclei and cytosol of the epithelium.
In the pterygial body, strong labeling was observed in the nuclei and cytosol of the epithelium and proliferating subepithelial connective tissue.
In normal conjunctival specimens, only trace immunoreactivity of both proteins was observed in the epithelial and stromal layers.
Exposures of ultraviolet (330 nm, 48.32 ± 0.55 J/cm2) or blue light (400 nm, 293.0 ± 2.0 J/cm2) to rat eyes enhanced labeling of 4-HHE- and 4-HNE-modified proteins in the nuclei of conjunctival epithelium.
Protein modifications by biologically active aldehydes are a molecular event involved in the development of pterygia.
American Psychological Association (APA)
Sano, Ichiya& Kaidzu, Sachiko& Tanito, Masaki& Hara, Katsunori& Okuno, Tsutomu& Ohira, Akihiro. 2013. 4-Hydroxyhexenal- and 4-Hydroxynonenal-Modified Proteins in Pterygia. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-484159
Modern Language Association (MLA)
Sano, Ichiya…[et al.]. 4-Hydroxyhexenal- and 4-Hydroxynonenal-Modified Proteins in Pterygia. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-484159
American Medical Association (AMA)
Sano, Ichiya& Kaidzu, Sachiko& Tanito, Masaki& Hara, Katsunori& Okuno, Tsutomu& Ohira, Akihiro. 4-Hydroxyhexenal- and 4-Hydroxynonenal-Modified Proteins in Pterygia. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-484159
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484159