Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect
Joint Authors
Wang, Yuji
Zhao, Ming
Wang, Yaonan
Peng, Shiqi
Cui, Chunying
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Alsterpaullone, a small molecule cyclin-dependent kinase (CDK) inhibitor, regulates the cell cycle progression.
Beyond death-inducing properties, we identified the effect of alsterpaullone on cycle procedure and apoptosis of HeLa cell.
It was found that alsterpaullone inhibited HeLa cells in a time-dependent (0–72 h) and dose-dependent (0–30 μM) manner.
In the presence of alsterpaullone, HeLa cells were arrested in G2/M prior to undergoing apoptosis via a mechanism that is involved in the regulation of various antiapoptotic genes, DNA-repair, transcription, and cell cycle progression.
Compared to controls, alsterpaullone effectively prevented HeLa cells from entering S-phase.
These potential therapeutic efficacies could be correlated with the activation of caspase-3.
American Psychological Association (APA)
Cui, Chunying& Wang, Yuji& Wang, Yaonan& Zhao, Ming& Peng, Shiqi. 2013. Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect. Journal of Analytical Methods in Chemistry،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-484164
Modern Language Association (MLA)
Cui, Chunying…[et al.]. Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect. Journal of Analytical Methods in Chemistry No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-484164
American Medical Association (AMA)
Cui, Chunying& Wang, Yuji& Wang, Yaonan& Zhao, Ming& Peng, Shiqi. Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect. Journal of Analytical Methods in Chemistry. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-484164
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484164