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The Role of Vitamin D in Primary Biliary Cirrhosis : Possible Genetic and Cell Signaling Mechanisms
Joint Authors
Lương, Khanh vinh quốc
Nguyễn, Lan Thi Hoàng
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Primary biliary cirrhosis (PBC) is an immune-mediated chronic inflammatory disease of the liver of unknown etiology.
Vitamin D deficiency is highly prevalent in patients with PBC, and many studies have demonstrated the significant effect of calcitriol on liver cell physiology.
Vitamin D has antiproliferative and antifibrotic effects on liver fibrosis.
Genetic studies have provided an opportunity to determine which proteins link vitamin D to PBC pathology (e.g., the major histocompatibility complex class II molecules, the vitamin D receptor, toll-like receptors, apolipoprotein E, Nramp1, and cytotoxic T lymphocyte antigen-4).
Vitamin D also exerts its effect on PBC through cell signaling mechanisms, that is, matrix metalloproteinases, prostaglandins, reactive oxygen species, and the transforming growth factor betas.
In conclusion, vitamin D may have a beneficial role in the treatment of PBC.
The best form of vitamin D for use in the PBC is calcitriol because it is the active form of vitamin D3 metabolite, and its receptors are present in the sinusoidal endothelial cells, Kupffer cells, and stellate cells of normal livers, as well as in the biliary cell line.
American Psychological Association (APA)
Lương, Khanh vinh quốc& Nguyễn, Lan Thi Hoàng. 2013. The Role of Vitamin D in Primary Biliary Cirrhosis : Possible Genetic and Cell Signaling Mechanisms. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-484172
Modern Language Association (MLA)
Lương, Khanh vinh quốc& Nguyễn, Lan Thi Hoàng. The Role of Vitamin D in Primary Biliary Cirrhosis : Possible Genetic and Cell Signaling Mechanisms. Gastroenterology Research and Practice No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-484172
American Medical Association (AMA)
Lương, Khanh vinh quốc& Nguyễn, Lan Thi Hoàng. The Role of Vitamin D in Primary Biliary Cirrhosis : Possible Genetic and Cell Signaling Mechanisms. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-484172
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484172