Tissue Reactivity of the 14F7 Mab Raised against N-Glycolyl GM3 Ganglioside in Tumors of Neuroectodermal, Mesodermal, and Epithelial Origin
Joint Authors
Calzado, Enrique Rengifo
Cedeño, Mercedes
Carr, Adriana
Quintana, Yisel
Ríos, Martha
Rengifo, Charles E.
Blanco, Rancés
Frómeta, Milagros
Blanco, Damián
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The expression of N-glycolylneuraminic acid forming the structure of gangliosides and/or other glycoconjugates (Hanganutziu-Deicher antigen) in human has been considered as a tumor-associated antigen.
Specifically, some reports of 14F7 Mab (a highly specific Mab raised against N-glycolyl GM3 ganglioside) reactivity in human tumors have been recently published.
Nevertheless, tumors of epithelial origin have been mostly evaluated.
The goal of the present paper was to evaluate the immunohistochemical recognition of 14F7 Mab in different human tumors of neuroectodermal, mesodermal, and epithelial origins using an immunoperoxidase staining method.
Samples of fetal, normal, and reactive astrocytosis of the brain were also included in the study.
In general, nontumoral tissues, as well as, low-grade brain tumors showed no or a limited immunoreaction with 14F7 Mab.
Nevertheless, high-grade astrocytomas (III-IV) and neuroblastomas, as well as, sarcomas and thyroid carcinomas were mostly reactive with 14F7.
No reaction was evidenced in medulloblastomas and ependymoblastomas.
Our data suggest that the expression of N-glycolyl GM3 ganglioside could be related to the aggressive behavior of malignant cells, without depending on the tumor origin.
Our data could also support the possible use of N-glycolyl GM3 as a target for both active and passive immunotherapies of malignancies expressing this molecule.
American Psychological Association (APA)
Blanco, Rancés& Quintana, Yisel& Blanco, Damián& Cedeño, Mercedes& Rengifo, Charles E.& Frómeta, Milagros…[et al.]. 2013. Tissue Reactivity of the 14F7 Mab Raised against N-Glycolyl GM3 Ganglioside in Tumors of Neuroectodermal, Mesodermal, and Epithelial Origin. Journal of Biomarkers،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-484184
Modern Language Association (MLA)
Blanco, Rancés…[et al.]. Tissue Reactivity of the 14F7 Mab Raised against N-Glycolyl GM3 Ganglioside in Tumors of Neuroectodermal, Mesodermal, and Epithelial Origin. Journal of Biomarkers No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-484184
American Medical Association (AMA)
Blanco, Rancés& Quintana, Yisel& Blanco, Damián& Cedeño, Mercedes& Rengifo, Charles E.& Frómeta, Milagros…[et al.]. Tissue Reactivity of the 14F7 Mab Raised against N-Glycolyl GM3 Ganglioside in Tumors of Neuroectodermal, Mesodermal, and Epithelial Origin. Journal of Biomarkers. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-484184
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484184