Efficacy and Tolerability of the Association of Sibutramine and Orlistat for Six Months in Overweight and Obese Patients
Joint Authors
Mancini, Marcio C.
Halpern, Alfredo
de Melo, Maria Edna
Pepe, Renata B.
Beyruti, Mônica
Monegaglia, Ana Paola
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
To assess the efficacy and tolerability of the association sibutramine (10–20 mg/day) and orlistat (120 mg 2-3 times a day) in the treatment of obesity in a six-month open trial.
Methods.
446 overweight and obese patients who sought treatment for obesity in a private clinic were assessed every 2 weeks during a period of 3 and 6 months.
Results.
After 3 months, the mean weight loss was 10.5 kg (-9.8% of the initial weight, n=263), and after 6 months, the mean weight loss was 13.9 kg (-12.8% of the initial weight, n=97).
The tolerability of such association was quite acceptable and coherent with the action mechanism of each component.
Conclusions.
The association of orlistat and sibutramine is quite efficient and it seems to promote a higher rate of weight loss than that reported in clinical studies performed with each drug separately.
American Psychological Association (APA)
Halpern, Alfredo& Pepe, Renata B.& Monegaglia, Ana Paola& Beyruti, Mônica& de Melo, Maria Edna& Mancini, Marcio C.. 2010. Efficacy and Tolerability of the Association of Sibutramine and Orlistat for Six Months in Overweight and Obese Patients. Journal of Obesity،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-484193
Modern Language Association (MLA)
Halpern, Alfredo…[et al.]. Efficacy and Tolerability of the Association of Sibutramine and Orlistat for Six Months in Overweight and Obese Patients. Journal of Obesity No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-484193
American Medical Association (AMA)
Halpern, Alfredo& Pepe, Renata B.& Monegaglia, Ana Paola& Beyruti, Mônica& de Melo, Maria Edna& Mancini, Marcio C.. Efficacy and Tolerability of the Association of Sibutramine and Orlistat for Six Months in Overweight and Obese Patients. Journal of Obesity. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-484193
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484193