Pathologies Associated with Serum IgG4 Elevation
Joint Authors
Daniel, Laurent
Grados, Aurélie
Bernit, Emmanuelle
Boucraut, José
Harle, Jean-Robert
Ebbo, Mikael
Schleinitz, Nicolas
Vély, Frédéric
Source
International Journal of Rheumatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Statement of Purpose.
IgG4-related disease (IgG4-RD) is usually associated to an increase of serum IgG4 levels.
However other conditions have also been associated to high serum IgG4 levels.
Methods.
All IgG subclasses analyses performed in our hospital over a one-year period were analyzed.
When IgG4 level were over 1.35 g/L, the patient’s clinical observation was analyzed and both final diagnosis and reason leading to IgG subclasses analysis were recorded.
Only polyclonal increases of IgG4 were considered.
Summary of the Results.
On 646 IgG subclass analysis performed, 59 patients had serum IgG4 over 1.35 g/L.
The final diagnosis associated to serum IgG4 increase was very variable.
Most patients (25%) presented with repeated infections, 13.5% with autoimmune diseases, and 10% with IgG4-RD.
Other patients presented with cancer, primary immune deficiencies, idiopathic interstitial lung disease, cystic fibrosis, histiocytosis, or systemic vasculitis and 13.5% presented with various pathologies or no diagnosis.
Mean IgG4 levels and IgG4/IgG ratio were higher in IgG4-RD than in other pathologies associated to elevated IgG4 levels.
Conclusions.
Our study confirms that elevation of serum IgG4 is not specific to IgG4-RD.
Before retaining IgG4-RD diagnosis in cases of serum IgG4 above 1.35 g/L, several other pathological conditions should be excluded.
American Psychological Association (APA)
Ebbo, Mikael& Grados, Aurélie& Bernit, Emmanuelle& Vély, Frédéric& Boucraut, José& Harle, Jean-Robert…[et al.]. 2012. Pathologies Associated with Serum IgG4 Elevation. International Journal of Rheumatology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-484219
Modern Language Association (MLA)
Ebbo, Mikael…[et al.]. Pathologies Associated with Serum IgG4 Elevation. International Journal of Rheumatology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-484219
American Medical Association (AMA)
Ebbo, Mikael& Grados, Aurélie& Bernit, Emmanuelle& Vély, Frédéric& Boucraut, José& Harle, Jean-Robert…[et al.]. Pathologies Associated with Serum IgG4 Elevation. International Journal of Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-484219
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484219