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Microencapsulated Bifidobacterium longum subsp. infantis ATCC 15697 Favorably Modulates Gut Microbiota and Reduces Circulating Endotoxins in F344 Rats
Joint Authors
Rodes, Laetitia
Tomaro-Duchesneau, Catherine
Saha, Shyamali
Prakash, Satya
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The gut microbiota is a bacterial bioreactor whose composition is an asset for human health.
However, circulating gut microbiota derived endotoxins cause metabolic endotoxemia, promoting metabolic and liver diseases.
This study investigates the potential of orally delivered microencapsulated Bifidobacterium infantis ATCC 15697 to modulate the gut microbiota and reduce endotoxemia in F344 rats.
The rats were gavaged daily with saline or microencapsulated B.
infantis ATCC 15697.
Following 38 days of supplementation, the treated rats showed a significant (P < 0.05) increase in fecal Bifidobacteria (4.34 ± 0.46 versus 2.45 ± 0.25% of total) and B.
infantis (0.28 ± 0.21 versus 0.52 ± 0.12 % of total) and a significant (P < 0.05) decrease in fecal Enterobacteriaceae (0.80 ± 0.45 versus 2.83 ± 0.63% of total) compared to the saline control.
In addition, supplementation with the probiotic formulation reduced fecal (10.52 ± 0.18 versus 11.29 ± 0.16 EU/mg; P = 0.01) and serum (0.33 ± 0.015 versus 0.30 ± 0.015 EU/mL; P = 0.25) endotoxins.
Thus, microencapsulated B.
infantis ATCC 15697 modulates the gut microbiota and reduces colonic and serum endotoxins.
Future preclinical studies should investigate the potential of the novel probiotic formulation in metabolic and liver diseases.
American Psychological Association (APA)
Rodes, Laetitia& Saha, Shyamali& Tomaro-Duchesneau, Catherine& Prakash, Satya. 2014. Microencapsulated Bifidobacterium longum subsp. infantis ATCC 15697 Favorably Modulates Gut Microbiota and Reduces Circulating Endotoxins in F344 Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-484226
Modern Language Association (MLA)
Rodes, Laetitia…[et al.]. Microencapsulated Bifidobacterium longum subsp. infantis ATCC 15697 Favorably Modulates Gut Microbiota and Reduces Circulating Endotoxins in F344 Rats. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-484226
American Medical Association (AMA)
Rodes, Laetitia& Saha, Shyamali& Tomaro-Duchesneau, Catherine& Prakash, Satya. Microencapsulated Bifidobacterium longum subsp. infantis ATCC 15697 Favorably Modulates Gut Microbiota and Reduces Circulating Endotoxins in F344 Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-484226
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484226