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Utility of Tissue Transglutaminase Immunohistochemistry in Pediatric Duodenal Biopsies : Patterns of Expression and Role in Celiac Disease—A Clinicopathologic Review
Joint Authors
Houston, Ronald H.
Prasad, Vinay
Almarzooqi, Saeeda
Source
Pathology Research International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Tissue transglutaminase (tTG) is a ubiquitous multifunctional protein.
It has roles in various cellular processes.
tTG is a major target of autoantibodies in celiac disease, and its expression by immunohistochemistry in pediatric celiac disease has not been fully examined.
We studied tTG expression in 78 pediatric duodenal biopsies by utilizing an antibody to transglutaminase 2.
Serum tTG was positive in all celiac cases evaluated.
Serum antiserum endomysial antibody (EMA) and tTG were negative in all control subjects and in inflammatory bowel disease and eosinophilic gastroenteritis.
There was a statistically significant difference between cases of celiac disease and normal controls in terms of tTG immunohistochemical staining in duodenal biopsies surface epithelium (P value = 0.0012).
There was no significant statistical difference in terms of staining of the villous surface or crypt between the cases of celiac disease and cases with IBD (P value = 0.5970 and 0.5227, resp.).
There was no detected correlation between serum tTG values and immunohistochemical positivity on duodenal biopsy in cases of celiac disease (P value = 1).
There was no relationship between Marsh classification and positivity of villous surface for tTG (P value = 0.4955).
We conclude that tTG has limited utility in diagnosis of celiac disease in pediatric duodenal biopsies.
American Psychological Association (APA)
Almarzooqi, Saeeda& Houston, Ronald H.& Prasad, Vinay. 2013. Utility of Tissue Transglutaminase Immunohistochemistry in Pediatric Duodenal Biopsies : Patterns of Expression and Role in Celiac Disease—A Clinicopathologic Review. Pathology Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-484242
Modern Language Association (MLA)
Almarzooqi, Saeeda…[et al.]. Utility of Tissue Transglutaminase Immunohistochemistry in Pediatric Duodenal Biopsies : Patterns of Expression and Role in Celiac Disease—A Clinicopathologic Review. Pathology Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-484242
American Medical Association (AMA)
Almarzooqi, Saeeda& Houston, Ronald H.& Prasad, Vinay. Utility of Tissue Transglutaminase Immunohistochemistry in Pediatric Duodenal Biopsies : Patterns of Expression and Role in Celiac Disease—A Clinicopathologic Review. Pathology Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-484242
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484242