Metabolite Profiling in the Pursuit of Biomarkers for IVF Outcome : The Case for Metabolomics Studies
Joint Authors
Fisher, Julie
Sharma, Vinay
McRae, Cassey
Source
International Journal of Reproductive Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-16
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Background.
This paper presents the literature on biomarkers of in vitro fertilisation (IVF) outcome, demonstrating the progression of these studies towards metabolite profiling, specifically metabolomics.
The need for more, and improved, metabolomics studies in the field of assisted conception is discussed.
Methods.
Searches were performed on ISI Web of Knowledge SM for literature associated with biomarkers of oocyte and embryo quality, and biomarkers of IVF outcome in embryo culture medium, follicular fluid (FF), and blood plasma in female mammals.
Results.
Metabolomics in the field of female reproduction is still in its infancy.
Metabolomics investigations of embryo culture medium for embryo selection have been the most common, but only within the last five years.
Only in 2012 has the first metabolomics investigation of FF for biomarkers of oocyte quality been reported.
The only metabolomics studies of human blood plasma in this context have been aimed at identifying women with polycystic ovary syndrome (PCOS).
Conclusions.
Metabolomics is becoming more established in the field of assisted conception, but the studies performed so far have been preliminary and not all potential applications have yet been explored.
With further improved metabolomics studies, the possibility of identifying a method for predicting IVF outcome may become a reality.
American Psychological Association (APA)
McRae, Cassey& Sharma, Vinay& Fisher, Julie. 2013. Metabolite Profiling in the Pursuit of Biomarkers for IVF Outcome : The Case for Metabolomics Studies. International Journal of Reproductive Medicine،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-484266
Modern Language Association (MLA)
McRae, Cassey…[et al.]. Metabolite Profiling in the Pursuit of Biomarkers for IVF Outcome : The Case for Metabolomics Studies. International Journal of Reproductive Medicine No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-484266
American Medical Association (AMA)
McRae, Cassey& Sharma, Vinay& Fisher, Julie. Metabolite Profiling in the Pursuit of Biomarkers for IVF Outcome : The Case for Metabolomics Studies. International Journal of Reproductive Medicine. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-484266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484266