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Functional Diversity of the Schistosoma mansoni Tyrosine Kinases
Joint Authors
Andrade, Luiza F.
de Oliveira, Guilherme Corrêa
Nahum, Laila A.
Avelar, Lívia G. A.
Source
Journal of Signal Transduction
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Schistosoma mansoni, one of the causative agents of schistosomiasis, has a complex life cycle infecting over 200 million people worldwide.
Such a successful and prolific parasite life cycle has been shown to be dependent on the adaptive interaction between the parasite and hosts.
Tyrosine kinases (TKs) play a key role in signaling pathways as demonstrated by a large body of experimental work in eukaryotes.
Furthermore, comparative genomics have allowed the identification of TK homologs and provided insights into the functional role of TKs in several biological systems.
Finally, TK structural biology has provided a rational basis for obtaining selective inhibitors directed to the treatment of human diseases.
This paper covers the important aspects of the phospho-tyrosine signaling network in S.
mansoni, Caenorhabditis elegans, and humans, the main process of functional diversification of TKs, that is, protein-domain shuffling, and also discusses TKs as targets for the development of new anti-schistosome drugs.
American Psychological Association (APA)
Avelar, Lívia G. A.& Nahum, Laila A.& Andrade, Luiza F.& de Oliveira, Guilherme Corrêa. 2011. Functional Diversity of the Schistosoma mansoni Tyrosine Kinases. Journal of Signal Transduction،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-484286
Modern Language Association (MLA)
Avelar, Lívia G. A.…[et al.]. Functional Diversity of the Schistosoma mansoni Tyrosine Kinases. Journal of Signal Transduction No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-484286
American Medical Association (AMA)
Avelar, Lívia G. A.& Nahum, Laila A.& Andrade, Luiza F.& de Oliveira, Guilherme Corrêa. Functional Diversity of the Schistosoma mansoni Tyrosine Kinases. Journal of Signal Transduction. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-484286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484286