4-Hydroxychalcone Attenuates Hyperaldosteronism, Inflammation, and Renal Injury in Cryptochrome-Null Mice
Joint Authors
Dai, Bingguang
Zhang, Fuling
Yang, Bo
Liu, Yimin
Qu, Qi
Li, Xuelian
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
In the present study, we aimed to investigate the preventive effects of 4-hydroxychalcone (4HCH) on resistant hypertension.
We used cryptochrome-null mice, which characteristically show high plasma aldosterone levels, inflammation, and renal injury.
The cryptochrome-null mice received high-salt treatment and were treated orally with 4HCH 10 mg/kg, 4HCH 20 mg/kg, and 4HCH 40 mg/kg, respectively.
The salt administration in cryptochrome-null mice is able to induce an increase in systolic pressure which is associated with hyperaldosteronism, inflammation, and kidney injury.
Treatment with 40 mg/kg 4HCH reduced systolic hypertension, serum IL-1β, and TNF-α levels and suppressed the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and renal injury.
The impact of 4HCH on the hyperaldosteronism, inflammation, and kidney injury provides new insights for future development of therapeutic strategies in resistant hypertension.
American Psychological Association (APA)
Qu, Qi& Dai, Bingguang& Yang, Bo& Li, Xuelian& Liu, Yimin& Zhang, Fuling. 2014. 4-Hydroxychalcone Attenuates Hyperaldosteronism, Inflammation, and Renal Injury in Cryptochrome-Null Mice. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-484288
Modern Language Association (MLA)
Qu, Qi…[et al.]. 4-Hydroxychalcone Attenuates Hyperaldosteronism, Inflammation, and Renal Injury in Cryptochrome-Null Mice. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-484288
American Medical Association (AMA)
Qu, Qi& Dai, Bingguang& Yang, Bo& Li, Xuelian& Liu, Yimin& Zhang, Fuling. 4-Hydroxychalcone Attenuates Hyperaldosteronism, Inflammation, and Renal Injury in Cryptochrome-Null Mice. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-484288
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484288