Prenatal and Postnatal Polycyclic Aromatic Hydrocarbon Exposure, Airway Hyperreactivity, and Beta-2 Adrenergic Receptor Function in Sensitized Mouse Offspring
Joint Authors
Zhang, Xiang
Yan, Beizhan
Ho, Shuk-Mei
Maher, Christina
Zhang, Hanjie
Perera, Frederica
Chillrud, Steven
Miller, Rachel L.
McDonald, Jacob D.
Factor, Phillip
Chu, Sophie
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Despite data associating exposure to traffic-related polycyclic aromatic hydrocarbons (PAH) in asthma, mechanistic support has been limited.
We hypothesized that both prenatal and early postnatal exposure to PAH would increase airway hyperreactivity (AHR) and that the resulting AHR may be insensitive to treatment with a β2AR agonist drug, procaterol.
Further, we hypothesized that these exposures would be associated with altered β2AR gene expression and DNA methylation in mouse lungs.
Mice were exposed prenatally or postnatally to a nebulized PAH mixture versus negative control aerosol 5 days a week.
Double knockout β2AR mice were exposed postnatally only.
Prenatal exposure to PAH was associated with reduced β2AR gene expression among nonsensitized mice offspring, but not increases in DNA methylation or AHR.
Postnatal exposure to PAH was borderline associated with increased AHR among sensitized wildtype, but not knockout mice.
In the first study that delivers PAH aerosols to mice in a relatively physiological manner, small effects on AHR and β2AR gene expression, but not β2AR agonist drug activity, were observed.
If confirmed, the results may suggest that exposure to PAH, common ambient urban pollutants, affects β2AR function, although the impact on the efficacy of β2AR agonist drugs used in treating asthma remains uncertain.
American Psychological Association (APA)
Chu, Sophie& Zhang, Hanjie& Maher, Christina& McDonald, Jacob D.& Zhang, Xiang& Ho, Shuk-Mei…[et al.]. 2013. Prenatal and Postnatal Polycyclic Aromatic Hydrocarbon Exposure, Airway Hyperreactivity, and Beta-2 Adrenergic Receptor Function in Sensitized Mouse Offspring. Journal of Toxicology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-484304
Modern Language Association (MLA)
Chu, Sophie…[et al.]. Prenatal and Postnatal Polycyclic Aromatic Hydrocarbon Exposure, Airway Hyperreactivity, and Beta-2 Adrenergic Receptor Function in Sensitized Mouse Offspring. Journal of Toxicology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-484304
American Medical Association (AMA)
Chu, Sophie& Zhang, Hanjie& Maher, Christina& McDonald, Jacob D.& Zhang, Xiang& Ho, Shuk-Mei…[et al.]. Prenatal and Postnatal Polycyclic Aromatic Hydrocarbon Exposure, Airway Hyperreactivity, and Beta-2 Adrenergic Receptor Function in Sensitized Mouse Offspring. Journal of Toxicology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-484304
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484304