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Effect of Ivabradine on Endothelial Function in Diastolic and Right Heart Failure Patients
Joint Authors
Castillo-Martínez, Lilia
Martínez Memije, Raúl
Infante-Vázquez, Oscar
Vázquez-Ortíz, Zuilma
Orea-Tejeda, Arturo
Keirns-Davis, Candace
Narváez-David, René
Dorantes-García, Joel
Balderas-Muñoz, Karla
Source
Cardiology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Ivabradine is an If ion current inhibitor that has proved to reduce mortality in patients with systolic heart failure by slowing heart rate without decreasing myocardial contractility.
Photoplethysmography is a simple, low-cost optical technique that can evaluate vascular function and detect changes in blood flow, pulse, and swelling of tissular microvascular space.
Objective.
To evaluate the effect of ivabradine on endothelial function by photoplethysmography in diastolic and right heart failure patients.
Methodology.
15 patients were included (mean age of 78.1 ± 9.2 years) with optimally treated diastolic and right heart failure.
They underwent photoplethysmography before and after induced ischemia to evaluate the wave blood flow on the finger, using the maximum amplitude time/total time (MAT/TT) index.
Two measurements were made before and after oral Ivabradine (mean 12.5 mg a day during 6 months of followup).
Results.
In the study group, the MAT/TT index was 29.1 ± 2.2 versus 24.3 ± 3.2 (P=0.05) in basal recording and 30.4 ± 2.1 versus 23.3 ± 2.9 (P=0.002), before versus after ischemia and before versus after Ivabradine intervention, respectively.
Conclusions.
Ivabradine administration improves endothelial function (shear stress) in diastolic and right heart failure patients.
American Psychological Association (APA)
Orea-Tejeda, Arturo& Balderas-Muñoz, Karla& Castillo-Martínez, Lilia& Infante-Vázquez, Oscar& Martínez Memije, Raúl& Keirns-Davis, Candace…[et al.]. 2013. Effect of Ivabradine on Endothelial Function in Diastolic and Right Heart Failure Patients. Cardiology Research and Practice،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-484340
Modern Language Association (MLA)
Orea-Tejeda, Arturo…[et al.]. Effect of Ivabradine on Endothelial Function in Diastolic and Right Heart Failure Patients. Cardiology Research and Practice No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-484340
American Medical Association (AMA)
Orea-Tejeda, Arturo& Balderas-Muñoz, Karla& Castillo-Martínez, Lilia& Infante-Vázquez, Oscar& Martínez Memije, Raúl& Keirns-Davis, Candace…[et al.]. Effect of Ivabradine on Endothelial Function in Diastolic and Right Heart Failure Patients. Cardiology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-484340
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484340