KSHV-Encoded MicroRNAs : Lessons for Viral Cancer Pathogenesis and Emerging Concepts
Joint Authors
Findlay, Victoria
Jakymiw, Andrew
Qin, Zhiqiang
Parsons, Chris
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The human genome contains microRNAs (miRNAs), small noncoding RNAs that orchestrate a number of physiologic processes through regulation of gene expression.
Burgeoning evidence suggests that dysregulation of miRNAs may promote disease progression and cancer pathogenesis.
Virus-encoded miRNAs, exhibiting unique molecular signatures and functions, have been increasingly recognized as contributors to viral cancer pathogenesis.
A large segment of the existing knowledge in this area has been generated through characterization of miRNAs encoded by the human gamma-herpesviruses, including the Kaposi’s sarcoma-associated herpesvirus (KSHV).
Recent studies focusing on KSHV miRNAs have led to a better understanding of viral miRNA expression in human tumors, the identification of novel pathologic check points regulated by viral miRNAs, and new insights for viral miRNA interactions with cellular (“human”) miRNAs.
Elucidating the functional effects of inhibiting KSHV miRNAs has also provided a foundation for further translational efforts and consideration of clinical applications.
This paper summarizes recent literature outlining mechanisms for KSHV miRNA regulation of cellular function and cancer-associated pathogenesis, as well as implications for interactions between KSHV and human miRNAs that may facilitate cancer progression.
Finally, insights are offered for the clinical feasibility of targeting miRNAs as a therapeutic approach for viral cancers.
American Psychological Association (APA)
Qin, Zhiqiang& Jakymiw, Andrew& Findlay, Victoria& Parsons, Chris. 2012. KSHV-Encoded MicroRNAs : Lessons for Viral Cancer Pathogenesis and Emerging Concepts. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-484345
Modern Language Association (MLA)
Qin, Zhiqiang…[et al.]. KSHV-Encoded MicroRNAs : Lessons for Viral Cancer Pathogenesis and Emerging Concepts. International Journal of Cell Biology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-484345
American Medical Association (AMA)
Qin, Zhiqiang& Jakymiw, Andrew& Findlay, Victoria& Parsons, Chris. KSHV-Encoded MicroRNAs : Lessons for Viral Cancer Pathogenesis and Emerging Concepts. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-484345
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484345