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Amelioration of Cadmium-Produced Teratogenicity and Genotoxicity in Mice Given Arthrospira maxima (Spirulina) Treatment
Joint Authors
Argüelles-Velázquez, Nancy
Chamorro-Cevallos, Germán
Alvarez-González, Isela
Madrigal-Bujaidar, Eduardo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Evaluation of the effects of Arthrospira maxima (AM) was made, otherwise known as Spirulina, on the teratogenicity, genotoxicity, and DNA oxidation processes induced by cadmium (Cd).
Pregnant ICR mice were divided into groups and administered water, Cd only, AM only, or AM plus Cd.
AM was administered orally at doses of 200, 400, and 800 mg/kg from gestational day 0 (GD0) to GD17, and at GD7 there was an intraperitoneal challenge of Cd (1.5 mg/kg).
Cd only caused fetal malformations, including exencephaly, micrognathia, ablephary, microphthalmia, and clubfoot, as well as a significant increase in the quantity of micronucleated polychromatic erythrocytes (MNPE) and of micronucleated normochromatic erythrocytes (MNNE) in blood cells of both the mothers and their fetuses.
An increased level of oxidation was also found, measured by a rise in the levels of the adduct 8-hydroxy-2-deoxyguanosine.
In a dose-dependent manner, AM significantly reduced the number of external, visceral, and skeletal malformations, the quantity of MNPE and MNNE, and the level of DNA oxidation.
The results suggest that AM may reduce the genotoxic effects and rates of congenital malformations caused by exposure to Cd in utero and that the antioxidant activity of this cyanobacterium could be responsible, at least in part, for producing this effect.
American Psychological Association (APA)
Argüelles-Velázquez, Nancy& Alvarez-González, Isela& Madrigal-Bujaidar, Eduardo& Chamorro-Cevallos, Germán. 2013. Amelioration of Cadmium-Produced Teratogenicity and Genotoxicity in Mice Given Arthrospira maxima (Spirulina) Treatment. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-484399
Modern Language Association (MLA)
Argüelles-Velázquez, Nancy…[et al.]. Amelioration of Cadmium-Produced Teratogenicity and Genotoxicity in Mice Given Arthrospira maxima (Spirulina) Treatment. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-484399
American Medical Association (AMA)
Argüelles-Velázquez, Nancy& Alvarez-González, Isela& Madrigal-Bujaidar, Eduardo& Chamorro-Cevallos, Germán. Amelioration of Cadmium-Produced Teratogenicity and Genotoxicity in Mice Given Arthrospira maxima (Spirulina) Treatment. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-484399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484399