Complex and Multidimensional Lipid Raft Alterations in a Murine Model of Alzheimer's Disease
Joint Authors
Brenneman, Randall
Chadwick, Wayne
Maudsley, Stuart
Martin, Bronwen
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-56, 56 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-02
Country of Publication
Egypt
No. of Pages
56
Main Subjects
Abstract EN
Various animal models of Alzheimer's disease (AD) have been created to assist our appreciation of AD pathophysiology, as well as aid development of novel therapeutic strategies.
Despite the discovery of mutated proteins that predict the development of AD, there are likely to be many other proteins also involved in this disorder.
Complex physiological processes are mediated by coherent interactions of clusters of functionally related proteins.
Synaptic dysfunction is one of the hallmarks of AD.
Synaptic proteins are organized into multiprotein complexes in high-density membrane structures, known as lipid rafts.
These microdomains enable coherent clustering of synergistic signaling proteins.
We have used mass analytical techniques and multiple bioinformatic approaches to better appreciate the intricate interactions of these multifunctional proteins in the 3xTgAD murine model of AD.
Our results show that there are significant alterations in numerous receptor/cell signaling proteins in cortical lipid rafts isolated from 3xTgAD mice.
American Psychological Association (APA)
Chadwick, Wayne& Brenneman, Randall& Martin, Bronwen& Maudsley, Stuart. 2010. Complex and Multidimensional Lipid Raft Alterations in a Murine Model of Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-56.
https://search.emarefa.net/detail/BIM-484423
Modern Language Association (MLA)
Chadwick, Wayne…[et al.]. Complex and Multidimensional Lipid Raft Alterations in a Murine Model of Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-56.
https://search.emarefa.net/detail/BIM-484423
American Medical Association (AMA)
Chadwick, Wayne& Brenneman, Randall& Martin, Bronwen& Maudsley, Stuart. Complex and Multidimensional Lipid Raft Alterations in a Murine Model of Alzheimer's Disease. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-56.
https://search.emarefa.net/detail/BIM-484423
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484423