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Gene Expression Patterns Underlying the Reinstatement of Plasticity in the Adult Visual System
Joint Authors
Castrén, Eero
Tiraboschi, Ettore
Maffei, Lamberto
Auvinen, Petri
Maya-Vetencourt, José Fernando
Guirado, Ramon
Greco, Dario
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The nervous system is highly sensitive to experience during early postnatal life, but this phase of heightened plasticity decreases with age.
Recent studies have demonstrated that developmental-like plasticity can be reactivated in the visual cortex of adult animals through environmental or pharmacological manipulations.
These findings provide a unique opportunity to study the cellular and molecular mechanisms of adult plasticity.
Here we used the monocular deprivation paradigm to investigate large-scale gene expression patterns underlying the reinstatement of plasticity produced by fluoxetine in the adult rat visual cortex.
We found changes, confirmed with RT-PCRs, in gene expression in different biological themes, such as chromatin structure remodelling, transcription factors, molecules involved in synaptic plasticity, extracellular matrix, and excitatory and inhibitory neurotransmission.
Our findings reveal a key role for several molecules such as the metalloproteases Mmp2 and Mmp9 or the glycoprotein Reelin and open up new insights into the mechanisms underlying the reopening of the critical periods in the adult brain.
American Psychological Association (APA)
Tiraboschi, Ettore& Guirado, Ramon& Greco, Dario& Auvinen, Petri& Maya-Vetencourt, José Fernando& Maffei, Lamberto…[et al.]. 2013. Gene Expression Patterns Underlying the Reinstatement of Plasticity in the Adult Visual System. Neural Plasticity،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-484452
Modern Language Association (MLA)
Tiraboschi, Ettore…[et al.]. Gene Expression Patterns Underlying the Reinstatement of Plasticity in the Adult Visual System. Neural Plasticity No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-484452
American Medical Association (AMA)
Tiraboschi, Ettore& Guirado, Ramon& Greco, Dario& Auvinen, Petri& Maya-Vetencourt, José Fernando& Maffei, Lamberto…[et al.]. Gene Expression Patterns Underlying the Reinstatement of Plasticity in the Adult Visual System. Neural Plasticity. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-484452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484452