Anti-Inflammatory Effects of Epoxyeicosatrienoic Acids
Joint Authors
Thomson, Scott J.
Bishop-Bailey, David
Askari, Ara
Source
International Journal of Vascular Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Epoxyeicosatrienoic acids (EETs) are generated by the activity of both selective and also more general cytochrome p450 (CYP) enzymes on arachidonic acid and inactivated largely by soluble epoxide hydrolase (sEH), which converts them to their corresponding dihydroxyeicosatrienoic acids (DHETs).
EETs have been shown to have a diverse range of effects on the vasculature including relaxation of vascular tone, cellular proliferation, and angiogenesis as well as the migration of smooth muscle cells.
This paper will highlight the growing evidence that EETs also mediate a number of anti-inflammatory effects in the cardiovascular system.
In particular, numerous studies have demonstrated that potentiation of EET activity using different methods can inhibit inflammatory gene expression and signalling pathways in endothelial cells and monocytes and in models of cardiovascular diseases.
The mechanisms by which EETs mediate their effects are largely unknown but may include direct binding to peroxisome proliferator-activated receptors (PPARs), G-protein coupled receptors (GPCRs), or transient receptor potential (TRP) channels, which initiate anti-inflammatory signalling cascades.
American Psychological Association (APA)
Thomson, Scott J.& Askari, Ara& Bishop-Bailey, David. 2012. Anti-Inflammatory Effects of Epoxyeicosatrienoic Acids. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-484454
Modern Language Association (MLA)
Thomson, Scott J.…[et al.]. Anti-Inflammatory Effects of Epoxyeicosatrienoic Acids. International Journal of Vascular Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-484454
American Medical Association (AMA)
Thomson, Scott J.& Askari, Ara& Bishop-Bailey, David. Anti-Inflammatory Effects of Epoxyeicosatrienoic Acids. International Journal of Vascular Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-484454
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484454