Porphyromonas gingivalis and Treponema denticola Mixed Microbial Infection in a Rat Model of Periodontal Disease
Joint Authors
Bhattacharyya, Indraneel
Kesavalu, Lakshmyya
Verma, Raj K.
Pola, Sheela
Meka, Archana
Wallet, Shannon M.
Rajapakse, Sunethra
Nair, Madhu
Hamrick, Clayton
Aukhil, Ikramuddin
Source
Interdisciplinary Perspectives on Infectious Diseases
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Porphyromonas gingivalis and Treponema denticola are periodontal pathogens that express virulence factors associated with the pathogenesis of periodontitis.
In this paper we tested the hypothesis that P.
gingivalis and T.
denticola are synergistic in terms of virulence; using a model of mixed microbial infection in rats.
Groups of rats were orally infected with either P.
gingivalis or T.
denticola or mixed microbial infections for 7 and 12 weeks.
P.
gingivalis genomic DNA was detected more frequently by PCR than T.
denticola.
Both bacteria induced significantly high IgG, IgG2b, IgG1, IgG2a antibody levels indicating a stimulation of Th1 and Th2 immune response.
Radiographic and morphometric measurements demonstrated that rats infected with the mixed infection exhibited significantly more alveolar bone loss than shaminfected control rats.
Histology revealed apical migration of junctional epithelium, rete ridge elongation, and crestal alveolar bone resorption; resembling periodontal disease lesion.
These results showed that P.
gingivalis and T.
denticola exhibit no synergistic virulence in a rat model of periodontal disease.
American Psychological Association (APA)
Verma, Raj K.& Rajapakse, Sunethra& Meka, Archana& Hamrick, Clayton& Pola, Sheela& Bhattacharyya, Indraneel…[et al.]. 2010. Porphyromonas gingivalis and Treponema denticola Mixed Microbial Infection in a Rat Model of Periodontal Disease. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-484456
Modern Language Association (MLA)
Verma, Raj K.…[et al.]. Porphyromonas gingivalis and Treponema denticola Mixed Microbial Infection in a Rat Model of Periodontal Disease. Interdisciplinary Perspectives on Infectious Diseases No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-484456
American Medical Association (AMA)
Verma, Raj K.& Rajapakse, Sunethra& Meka, Archana& Hamrick, Clayton& Pola, Sheela& Bhattacharyya, Indraneel…[et al.]. Porphyromonas gingivalis and Treponema denticola Mixed Microbial Infection in a Rat Model of Periodontal Disease. Interdisciplinary Perspectives on Infectious Diseases. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-484456
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484456