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Beyond Poiseuille : Preservation Fluid Flow in an Experimental Model
Joint Authors
Singh, Saurabh
Callaghan, Chris J.
Callaghan, Paul T.
Randle, Lucy V.
Watson, Christopher J. E.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Poiseuille’s equation describes the relationship between fluid viscosity, pressure, tubing diameter, and flow, yet it is not known if cold organ perfusion systems follow this equation.
We investigated these relationships in an ex vivo model and aimed to offer some rationale for equipment selection.
Increasing the cannula size from 14 to 20 Fr increased flow rate by a mean (SD) of 13 (12)%.
Marshall’s hyperosmolar citrate was three times less viscous than UW solution, but flows were only 45% faster.
Doubling the bag pressure led to a mean (SD) flow rate increase of only 19 (13)%, not twice the rate.
When external pressure devices were used, 100 mmHg of continuous pressure increased flow by a mean (SD) of 43 (17)% when compared to the same pressure applied initially only.
Poiseuille’s equation was not followed; this is most likely due to “slipping” of preservation fluid within the plastic tubing.
Cannula size made little difference over the ranges examined; flows are primarily determined by bag pressure and fluid viscosity.
External infusor devices require continuous pressurisation to deliver high flow.
Future studies examining the impact of perfusion variables on graft outcomes should include detailed equipment descriptions.
American Psychological Association (APA)
Singh, Saurabh& Randle, Lucy V.& Callaghan, Paul T.& Watson, Christopher J. E.& Callaghan, Chris J.. 2013. Beyond Poiseuille : Preservation Fluid Flow in an Experimental Model. Journal of Transplantation،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-484475
Modern Language Association (MLA)
Singh, Saurabh…[et al.]. Beyond Poiseuille : Preservation Fluid Flow in an Experimental Model. Journal of Transplantation No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-484475
American Medical Association (AMA)
Singh, Saurabh& Randle, Lucy V.& Callaghan, Paul T.& Watson, Christopher J. E.& Callaghan, Chris J.. Beyond Poiseuille : Preservation Fluid Flow in an Experimental Model. Journal of Transplantation. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-484475
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484475