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Phytochemical Analysis and Antimalarial Activity Aqueous Extract of Lecaniodiscus cupanioides Root
Joint Authors
Abdulsalam, Taoheed Adedeji
Akanji, Musbau Adewumi
Nafiu, Mikhail Olugbemiro
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-01
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Root aqueous extract of Lecaniodiscus cupanioides was evaluated for antimalarial activity and analyzed for its phytochemical constituents.
Twenty-four (24) albino mice were infected by intraperitoneal injection of standard inoculum of chloroquine sensitive Plasmodium berghei (NK 65).
The animals were randomly divided into 6 groups of 3 mice each.
Group 1 served as the control while groups II–IV were orally administered 50, 150, and 250 mg/kg body weights of extract.
Groups 5 and 6 received 1.75 and 5 mg/kg of artesunate and chloroquine, respectively.
The results of the phytochemical analysis showed the presence of alkaloids (2.37%), saponin (0.336), tannin (0.012 per cent), phenol (0.008 per cent), and anthraquinone (0.002 per cent).
There was 100 per cent parasite inhibition in the chloroquine group and 70 per cent in the 50 mg/kg body weight on day 12, respectively.
The mean survival time (MST), for the control group was 14 days, artesunate 16 days, and chloroquine 30 days, while the groups that received 50 and 250 mg/kg body weight recorded similar MST of 17 days and the 150 mg/kg body weight group recorded 19 days.
The results obtained indicated that the aqueous extract of Lecaniodiscus cupanioides may provide an alternative antimalarial.
American Psychological Association (APA)
Nafiu, Mikhail Olugbemiro& Abdulsalam, Taoheed Adedeji& Akanji, Musbau Adewumi. 2013. Phytochemical Analysis and Antimalarial Activity Aqueous Extract of Lecaniodiscus cupanioides Root. Journal of Tropical Medicine،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-484481
Modern Language Association (MLA)
Nafiu, Mikhail Olugbemiro…[et al.]. Phytochemical Analysis and Antimalarial Activity Aqueous Extract of Lecaniodiscus cupanioides Root. Journal of Tropical Medicine No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-484481
American Medical Association (AMA)
Nafiu, Mikhail Olugbemiro& Abdulsalam, Taoheed Adedeji& Akanji, Musbau Adewumi. Phytochemical Analysis and Antimalarial Activity Aqueous Extract of Lecaniodiscus cupanioides Root. Journal of Tropical Medicine. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-484481
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484481