Effects of Methanol Extract of Breadfruit (Artocarpus altilis) on Atherogenic Indices and Redox Status of Cellular System of Hypercholesterolemic Male Rats
Joint Authors
Adaramoye, Oluwatosin Adekunle
Akanni, Olubukola Oyebimpe
Source
Advances in Pharmacological Sciences
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We investigated the effects of methanol extract of Artocarpus altilis (AA) on atherogenic indices and redox status of cellular system of rats fed with dietary cholesterol while Questran (QUE) served as standard.
Biochemical indices such as total cholesterol (TC), triglycerides (TG), low- and high-density lipoproteins-cholesterol (LDL-C and HDL-C), aspartate and alanine aminotransferases (AST and ALT), lactate dehydrogenase (LDH), reduced glutathione, glutathione-s-transferase, glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), and lipid peroxidation (LPO) were assessed.
Hypercholesterolemic (HC) rats had significantly increased relative weight of liver and heart.
Dietary cholesterol caused a significant increase (P<0.05) in the levels of serum, hepatic, and cardiac TC by 110%, 70%, and 85%, LDL-C by 79%, 82%, and 176%, and TG by 68%, 96%, and 62%, respectively.
Treatment with AA significantly reduced the relative weight of the organs and lipid parameters.
There were beneficial increases in serum and cardiac HDL-C levels in HC rats treated with AA.
In HC rats, serum LDH, ALT, and AST activities and levels of LPO were increased, whereas hepatic and cardiac SOD, CAT, and GPx were reduced.
All biochemical and histological alterations were ameliorated upon treatment with AA.
Extract of AA had protective effects against dietary cholesterol-induced hypercholesterolemia.
American Psychological Association (APA)
Adaramoye, Oluwatosin Adekunle& Akanni, Olubukola Oyebimpe. 2014. Effects of Methanol Extract of Breadfruit (Artocarpus altilis) on Atherogenic Indices and Redox Status of Cellular System of Hypercholesterolemic Male Rats. Advances in Pharmacological Sciences،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-484483
Modern Language Association (MLA)
Adaramoye, Oluwatosin Adekunle& Akanni, Olubukola Oyebimpe. Effects of Methanol Extract of Breadfruit (Artocarpus altilis) on Atherogenic Indices and Redox Status of Cellular System of Hypercholesterolemic Male Rats. Advances in Pharmacological Sciences No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-484483
American Medical Association (AMA)
Adaramoye, Oluwatosin Adekunle& Akanni, Olubukola Oyebimpe. Effects of Methanol Extract of Breadfruit (Artocarpus altilis) on Atherogenic Indices and Redox Status of Cellular System of Hypercholesterolemic Male Rats. Advances in Pharmacological Sciences. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-484483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484483