Mathematical Model of the Impact of a Nonantibiotic Treatment for Clostridium difficile on the Endemic Prevalence of Vancomycin-Resistant Enterococci in a Hospital Setting
Joint Authors
D'Agata, Erika M. C.
Webb, Glenn F.
Grima, Daniel T.
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Clostridium difficile-associated disease (CDAD) is treated using antibiotics, which often leads to the emergence of antibiotic-resistant bacteria such as vancomycin-resistant enterococci (VRE).
This study estimated the impact of a non antibiotic treatment for CDAD on VRE prevalence.
Methods.
A previously published model describing the impact of in-hospital antibiotic use on VRE prevalence was adapted to include CDAD treatment.
Simulations compared the prevalence of VRE when nonantibiotic versus antibiotic therapy was used.
Results.
Nonantibiotic treatment in 50% of CDAD patients resulted in an 18% relative reduction in the prevalence of VRE colonization compared with antibiotic use only.
Sensitivity analysis found the model to be most sensitive to rates of antibiotic initiation and discontinuation, prevalence of VRE in admitted patients, length of stay of colonized patients, probability of CDAD acquisition, and hand-washing compliance.
Conclusion.
Nonantibiotic treatment of patients hospitalized with CDAD may significantly reduce the incidence of VRE colonization.
American Psychological Association (APA)
Grima, Daniel T.& Webb, Glenn F.& D'Agata, Erika M. C.. 2012. Mathematical Model of the Impact of a Nonantibiotic Treatment for Clostridium difficile on the Endemic Prevalence of Vancomycin-Resistant Enterococci in a Hospital Setting. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-484523
Modern Language Association (MLA)
Grima, Daniel T.…[et al.]. Mathematical Model of the Impact of a Nonantibiotic Treatment for Clostridium difficile on the Endemic Prevalence of Vancomycin-Resistant Enterococci in a Hospital Setting. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-484523
American Medical Association (AMA)
Grima, Daniel T.& Webb, Glenn F.& D'Agata, Erika M. C.. Mathematical Model of the Impact of a Nonantibiotic Treatment for Clostridium difficile on the Endemic Prevalence of Vancomycin-Resistant Enterococci in a Hospital Setting. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-484523
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484523