The Aggregation of Huntingtin and α-Synuclein
Joint Authors
Chánez-Cárdenas, María Elena
Vázquez-Contreras, Edgar
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Huntington’s and Parkinson’s diseases are neurodegenerative disorders associated with unusual protein interactions.
Although the origin and evolution of these diseases are completely different, characteristic deposits of protein aggregates (huntingtin and α-synuclein resp.), are a common feature in both diseases.
After these observations, many studies are performed with both proteins.
Some of them try to understand the nature and driving forces of the aggregation process; others try to find a correlation between the genetic and failure in protein function.
Finally with the combination of both approaches, it was proposed that possible strategies deal with pathologic aggregation.
Unfortunately, if protein aggregation is a cause or a consequence of the neurodegeneration observed in these pathologies, it is still debatable.
This paper describes the process of aggregation of two proteins: huntingtin and α synuclein.
The characteristics of the aggregation reaction of these proteins have been followed with novel methods both in vivo and in vitro; these studies include both the combination with other proteins and the presence of various chemical compounds.
The ultimate goal of this study was to summarize recent findings on protein aggregation and its possible role as a therapeutic target in neurodegenerative diseases and their role in biomaterial science.
American Psychological Association (APA)
Chánez-Cárdenas, María Elena& Vázquez-Contreras, Edgar. 2012. The Aggregation of Huntingtin and α-Synuclein. Journal of Biophysics،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-484542
Modern Language Association (MLA)
Chánez-Cárdenas, María Elena& Vázquez-Contreras, Edgar. The Aggregation of Huntingtin and α-Synuclein. Journal of Biophysics No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-484542
American Medical Association (AMA)
Chánez-Cárdenas, María Elena& Vázquez-Contreras, Edgar. The Aggregation of Huntingtin and α-Synuclein. Journal of Biophysics. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-484542
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484542