Collagen VI and Hyaluronan : The Common Role in Breast Cancer
Joint Authors
Passi, Alberto
Karousou, Evgenia
Viola, Manuela
Vigetti, Davide
D'Angelo, Maria Luisa
Nikitovic, Dragana
De Luca, Giancarlo
Kouvidi, Katerina
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Collagen VI and hyaluronan are widely distributed extracellular matrix macromolecules that play a crucial role in tissue development and are highly expressed in cancers.
Both hyaluronan and collagen VI are upregulated in breast cancer, generating a microenvironment that promotes tumour progression and metastasis.
A growing number of studies show that these two molecules are involved in inflammation and angiogenesis by recruiting macrophages and endothelial cells, respectively.
Additionally, collagen VI induces epithelial-mesenchymal transition that is correlated to increased synthesis of hyaluronan in mammary cells.
Hyaluronan has also a specific role in cellular functions that depends mainly on the size of the polymer, whereas the effect of collagen VI in tumour progression may be the result of the intact molecule or the C5 peptide of α3(VI) chain, known as endotrophin.
Collectively, these findings strongly support the parallel role of these molecules in tumour progression and suggest that they may be used as prognostic factors for the breast cancer treatment.
American Psychological Association (APA)
Karousou, Evgenia& D'Angelo, Maria Luisa& Kouvidi, Katerina& Vigetti, Davide& Viola, Manuela& Nikitovic, Dragana…[et al.]. 2014. Collagen VI and Hyaluronan : The Common Role in Breast Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-484569
Modern Language Association (MLA)
Karousou, Evgenia…[et al.]. Collagen VI and Hyaluronan : The Common Role in Breast Cancer. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-484569
American Medical Association (AMA)
Karousou, Evgenia& D'Angelo, Maria Luisa& Kouvidi, Katerina& Vigetti, Davide& Viola, Manuela& Nikitovic, Dragana…[et al.]. Collagen VI and Hyaluronan : The Common Role in Breast Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-484569
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484569